Postdoctoral Fellow

England, Cambridgeshire
$38551.48 - $48325.96 per annum + excellent benefits
August 02 2017
The Wellcome Trust Sanger Institute
Position Type
Organization Type
Other Corporate
Job Type

Salary £31,115 to £39,004 plus excellent benefits. Fixed term for 3 years.

We are seeking to appoint a highly motivated Postdoctoral Fellow to join the Adams Faculty Team at the Wellcome Trust Sanger Institute.

Synthetic lethality is a powerful strategy for treating cancer which exploits somatic mutations found in cancer genomes to specifically kill cancer cells while leaving normal cells unharmed. The Experimental Cancer Genetics group ( aims to use isogenic cell line systems to identify synthetic lethal interactions, an approach used previously to identify clinically relevant gene interactions such as the interaction between BRCA1/2 and PARP.

We seek a talented biologist to lead our genetic screening efforts. The post holder will work with a group of postdocs and students to deploy CRISPR screening to identify synthetic lethal interactions and to explore the biology of these interactions. The role would suit someone with a background in cancer genetics or genome engineering. A background in vector construction and lentiviral production would be advantageous.

The project will involve high-throughput sequencing, high-throughput screening technologies, and is supported by a team of computational biologists. This project underpins a collaboration with the Netherlands Cancer Institute.

Essential Skills

  • PhD in a relevant subject area
  • Previous experience in tissue culture
  • Familiarity with molecular biology
  • Ability to work both independently and within a team
  • Ability to communicate effectively with collaborators and at group/external meetings

Ideal Skills

  • Gene editing
  • Lentiviral production

Other information


Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.

Closing date for applications: 7th September 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

The interviews will take place 2-4 weeks following the advert closure.