Associate Principal Scientist – Oncology Discovery Job

Boston, MA, US
July 31 2017
Organization Type
Associate Principal Scientist – Oncology Discovery:BIO004881


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

We are seeking a highly motivated associate principal scientist to join our Discovery Oncology team at Merck, Boston. The successful candidate will be responsible for validating novel immunotherapy targets and contributing to both biologics and small molecule drug discovery programs. Responsibilities include the development and execution of experimental strategies to define the mechanism of action of, and mechanism of resistance to, immune-therapeutic agents. S/he will perform in vitro and ex-vivo experiments to determine the functional effect(s) of candidate target activation/inhibition by using a variety of assays to interrogate immune end-points. Candidate will be involved in leading external collaborations with academic and industry partners. Candidate is expected to be up to date on advanced technologies for immunotherapy, actively apply new concepts as appropriate to continuously improve functional area capabilities as well as to keep abreast of published scientific literature.



- PhD in Immunology or Cancer Biology with relevant postdoctoral experience and a minimum of 3 years of industry experience.


- Candidate should have expertise in Immune Oncology and extensive experience with both T cell biology and myeloid biology (i.e. MDSCs).

- Candidate should have a solid understanding of current Immuno-Oncology approaches and motivation to advance new therapeutic targets

- Candidate is required to be a strong team player with excellent oral and written communication skills and with a demonstrated ability to work independently to design experiments, interpret data, troubleshoot, and suggest next steps.

- Candidate should have the ability to multitask and perform in matrixed, multifunctional teams

- Candidate is required to have excellent oral and written communication skills and with demonstrated ability to work independently to design and execute experiments, interpret data, troubleshoot and resolve technical challenges.

- Candidate must have expertise in developing in vitro and in vivo assays to investigate immune function and possess knowledge of technologies commonly used to assess immune endpoints.

- Candidate should have experience in the isolating, differentiating and manipulating primary human and mouse immune cells as well as experience in growth and maintenance of cell lines, proliferation and apoptosis assays, immunoassay techniques/platforms such as MLR, ELISA, Mesoscale


- Demonstrated project leadership in industrial or academic setting

- Experience in bio/pharmaceutical drug discovery research and animal tumor modeling

- Experience with multi-parameter FACS and data processing

- Experience either working with or leading collaborations with external academic, biotechnology, and contract research organizations.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. If you need an accommodation for the application process please email us at

Search Firm Representatives Please Read Carefully:

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

For more information about personal rights under Equal Employment Opportunity, visit:

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Primary Location: NA-US-MA-Boston

Job Type: Full Time

Employee Status: Regular

Travel: Yes, 10 % of the Time

Number of Openings: 1

Relocation Provided: None

Company Trade Name:Merck

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