PhD scholarship Mechanisms of stem cell dysfunction in muscular dystrophies

Employer
CIBIO - University of Trento
Location
Italy
Posted
July 24 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

Funded by Telethon Foundation. The project will be carried out at the Dulbecco Telethon Laboratory of Stem Cells and Regenerative Medicine at CIBIO-Centre for Integrative Biology http://www.cibio.unitn.it/220/dulbecco-telethon-laboratory-of-stem-cells-and-regenerative-medicine


Although under normal conditions muscle stem cells present a very powerful regenerative response, the regenerative potential is progressively lost in patients affected by Duchenne muscular dystrophy and fibrotic tissue progressively replaces muscle fibers leading to an impairment of muscle function. This study strives to the comprehension of the cellular and molecular events leading to fibrosis and defective regeneration in muscle, and may represent an important step toward the development of novel effective therapeutic approaches.


The candidate is expected to be familiar with basic techniques in cell (cell culture, transfection) and molecular biology (quantitative RT-PCR). Willingness to work with vertebrate animal models is required. Experience with primary cultures, immunofluorescences, Fluorescence-activated cell sorting (FACS) and ELISA techniques are preferential. Bioinformatics skills are also preferential, but not required.


For additional information please contact dr. Stefano Biressi (stefano.biressi@unitn.it)



This job comes from a partnership with Science Magazine and Euraxess