Mitochondrial metabolism and gender medicine: novel preclinical and clinical investigation tools
Applying “gender medicine” criteria to basic and clinical research has the potential to promote discovery of disease mechanisms and adequate therapy. Sexual hormones have a marked influence on mitochondrial biogenesis and function. It has been recently observed that sexual dimorphism phenomena affect cellular bioenergetics and the metabolic capacity of mitochondria. Further, mitochondrial dysfunction is at the basis of various pathologies that exhibit aspects of gender specificity. Aim of this project is to develop advanced methods for non-invasive diagnostics of cellular bioenergetics. The diagnostic tools will be applied in preclinical and clinical studies to investigate the contribution of mitochondrial dysfunctions in metabolic disorders in relation to the gender (male or female) of the subjects being investigated.
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