Postdoctoral studies (scholarship) in structural biology of TGF-beta superfamily coreceptors.

Employer
Karolinska Institutet
Location
Sweden
Posted
July 14 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

Division and duties


The research group of Luca Jovine at Karolinska Institutet has an opening for a postdoctoral fellow to study protein complexes involving TGF-beta superfamily coreceptors, with a focus on endoglin/CD105 - a key human glycoprotein involved in hereditary hemorrhagic telangiectasia type 1 (HHT1), preeclampsia and tumor angiogenesis. Parallel studies are also ongoing on a number of structurally related biological systems mediating fertilization as well as protection from bacterial infection.


For further information about our laboratory and recent examples, please see http://jovinelab.org and: Saito et al. Cell Rep. 19(9):1917-28 (2017)  [ http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30636-8 ]; Raj et al. Cell 169(7):1315-26 (2017) [ http://www.cell.com/cell/fulltext/S0092-8674(17)30594-9 ]; Bokhove et al. Proc. Natl. Acad. Sci. USA 113(6):1552-7 (2016) [ http://www.pnas.org/content/113/6/1552.long ].


The Department of Biosciences and Nutrition of Karolinska Institutet has state-of-the-art equipment for protein expression and purification, sample characterization (microscale thermophoresis, SEC-MALS) and in house X-ray/EM data collection (Rigaku Compact HomeLab with PILATUS 200K detector; http://ki.se/en/bionut/center-for-high-resolution-electron-microscopy-em). Frequent access to various synchrotron sites, as well as access to the newly established Cryo-EM Swedish National Facility (https://www.scilifelab.se/facilities/cryo-em/), are also available. With their close integration of academic and clinical research, KI and the Center for Innovative Medicine (CIMED) - to which our group also belongs - offer a highly international and collaborative environment for biomedical studies.


Qualifications

Candidates should have (or will be soon awarded) a PhD degree and must have a significant experience in studying protein-protein interactions, both biochemically and using either X-ray crystallography or single-particle cryo-EM. Proven experience with the latter and/or protein expression in eukaryotic cells will be a significant advantage. At least one first author paper in a high quality international peer-reviewed journal, fluency in English (both written and oral), good team spirit and a very strong personal drive to excel in science are required.


Entry requirements

Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish PhD or higher.


Type of scholarship

A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent. This educational scholarship is tax-exempt.


The amount is set for twelve months at a time and is paid out on a monthly basis. In exceptional cases, shorter periods may be acceptable.


Application process

An application must contain the following documents in English:


Personal letterCurriculum vitaeA complete list of publications and, if available, PDB depositionsA concise summary of previous and current work (maximum one page)Contact details of up to three references, specifying what is their connection with the candidateCopy of Ph.D. degree certificate (if available)The application is to be submitted on the MyNetwork recruitment system.


Contacts:

- Luca Jovine, Professor, +46-8-524 811 36

- Thomas Tinglöv, Head of Administration, +46-8-524 835 49



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