2 Post-Doc (Bioinformatics/ Immunology) & 2 Research (Cell Biology/Biomedical Engineering) positions

Location
Portugal (PT)
Salary
The fellowships value will be based on the rules of FCT. More information http://www.fct.pt
Posted
July 12 2017
Ref
BIM-ECM_INK-JULY-2017 AND BPD-ECM_INK-JULY-2017
Position Type
Full Time
Organization Type
Academia

Under the Consolidator ERC Grant – ECM_INK

3B’s Research Group

Biomaterials, Biodegradables and Biomimetics

University of Minho, Portugal

 

In the scope of the ERC Consolidator Grant “ECM_INK - Cells-self Extracellular Matrices-based Bioinks to create accurate 3D diseased skin tissue models”, the 3B’s Research Group (www.3bs.uminho.pt) from the University of Minho, Portugal, is opening 2 post-doctoral research positions in the fields of bioinformatics and immunology and 2 research positions in the fields of Cell biology and Biomedical Engineering.

The positions are aimed at young, committed and passionate researchers willing to develop multidisciplinary research integrating a team specifically gathered with the objective of building pathophysiological relevant in vitro 3D models of diseased skin under the scope of a prestigious 5 years ERC project awarded to Dr Alexandra Marques (http://3bs.uminho.pt/users/apmarques).

Autonomy, ambition, strong team spirit and commitment to research excellence, and willingness to participate in the activities of the group are expected. The applicant should have strong written and oral communication skills.

Good proficiency in the English language is required.

Duties will include design and execution of experiments, data processing, presentation and preparation for publication, and training of co-workers.

2 post-doctoral research positions:

Profile 1 - Bioinformatics

The successful applicant is expected to apply relevant bioinformatics, statistics and systems biology tools to perform analysis of genomic and transcriptomic data to generate models of the regulation of pathophysiological signalling pathways of skin diseases. The position will require the development of analysis solutions using established data-processing pipelines (e.g. for proteomics or image analysis; accessing online databases and repositories), novel coding (e.g. Matlab, Python) and statistical analysis (e.g. using ‘R’).

The post-doctoral researcher will also provide bioinformatics expertise to complementary works on the analysis and interpretation of large datasets produced from ‘-omics’ and high-content imaging methods.

The applicants should hold a PhD degree in Bioinformatics or related area with relevant experience in in silico modelling and data management and treatment. We are strongly interested in the position holder bringing new technical expertise from relevant fields including, but not limited to, skin biology and disease modelling.

Profile 2 - Immunology

The candidate is expected to apply the immunology expertise to define, throughout the different stages of the project, the conditions to generate in the 3D in vitro models an “innate” simplified immune system. Specific work on the pathophysiology of the autoimmune skin disease pemphigus vulgaris will be required for the development and validation of the respective model.

The post-doctoral researcher will also provide immunology-related expertise to complementary works on the development of biomaterial-based immunotherapies.

The applicants should hold a PhD degree in Cell Biology or related area with a strong background in immunology. We are strongly interested in the position holder bringing new technical expertise from relevant fields including, but not limited to, skin biology and diseases, and in vitro and in vivo models.

2 research positions:

Profile 1 - Cell Biology

The successful applicant is expected to develop fundamental research on tailoring cells extracellular matrices secretion and composition to be used in the generation of in vitro 3D models of diseased skin. The position will require the establishment, optimization and full characterization, using forefront genomic and proteomic tools, of cell cultures from patient’s biological material.

Collaborative effort in the development of new bioinks that will be used in the biofabrication of the models will play a significant part of the work to be developed.

Specific work on the pathophysiology of the genetic skin disease epidermolysis bullosa will be required for the development and validation of the respective model.

The applicants should hold a MSc degree in Cell Biology or related area. Experience and/or skills on animal cell culture, genomic or proteomic techniques and skin biology will be valued.  

Profile 2 -  Biomedical Engineering

The successful applicant is expected to develop research on the optimization of the bioprinting conditions to generate the in vitro 3D models of diseased skin. The position will require the tailoring of biomaterials properties as well as the definition of the processing window using the innovative elements of both the biofabrication and bioinks.

Collaborative effort in the development of new bioinks that will be used in the biofabrication of the models will play a significant part of the work to be developed.

Specific work on the creation of a branched structure within the models during the biofabrication aiming to generate a vascular-like structure will be required.

The applicants should hold a MSc degree in Biomedical Engineering or related area. Experience and/or skills on biofabrication techniques, biomaterials characterization and processing will be valued.  

Application, Details and Procedures: 

Please refer to  http://3bs.uminho.pt/positions  

Apply for 2 Post-Doc (Bioinformatics/ Immunology) & 2 Research (Cell Biology/Biomedical Engineering) positions

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