Prevention of asthma by treating the nose
The laboratory of Clinical Immunology is currently looking for a motivated PhD candidate for a research project on different factors that may contribute to the prevention of asthma. The laboratory of Clinical Immunology is part of the Department of Microbiology and Immunology (KU Leuven). Our research focuses on the mechanisms underlying chronic inflammatory diseases (rhinitis, sinusitis, asthma) with a special interest in regulation of the mucosal barrier function. The current project is supported by EUFOREA, ‘The European Forum for Research and Education in Allergy and Airway Diseases'.
In this PhD project we will study how proper treatment of upper airway disease may contribute to the prevention of asthma. Previous research in our laboratory has shown that upper and lower airways are linked with each other (‘united airway concept') via different neuronal mechanisms. In addition, new evidence shows that early intervention at the site of the nose and sinuses may lead to a reduction of asthma prevalence. This translational research project consists of in vitro research with human tissue, in vivo research on murine models of asthma and clinical research.
Given the translational nature of this research project, the likelihood of success to obtain a FWO fellowship is high.
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