Postdoc - Systems biology of kidney injury responses

Universiteit Leiden
June 19 2017
Position Type
Full Time
Organization Type

Kidney injury is critical in various human diseases and caused by diverse nephrotoxic drugs. The injury to the kidney is often confounded to the proximal tubular cells. Injury to the renal proximal tubular cells results in activation of various cell signalling pathways that initiate cellular repair and tissue regeneration, or activate the onset of cell death. Such stress response pathways are critical in normal cellular physiology and include e.g. KEAP1/Nrf2 pathway, DNA-damage response pathway, unfolded protein response, heatshock response. The aim of the project is to quantitatively assess the activation of these stress response and tissue regeneration pathways using high throughput transcriptomics approaches. This will involve both in vitro as well as in vivo approaches. The in vitro/ in vivo findings will be directly related to human data. Quantitative data on pathway activation will be integrated with computational biology modelling in collaboration with the postdoc in the project as well as collaborations with European partners in the project.   
The Postdoc candidate will work in the context of the Innovative Medicines Initiative project Translation Quantitative Systems Toxicology (TransQST), a 8 MEuro pan-European project with partners from academia and the European pharmaceutical industry. The TransQST project focuses on the implementation of quantitative mechanistic insights on the molecular mechanisms of liver, kidney, heart and intestinal injury in systems biology models that are predictive for the human target tissue injury outcome.

  • A PhD in relevant area; 

  • Enthusiastic and ambitious;

  • Independent thinker;

  • Expertise in molecular and cell biology, transcriptomics, signal transduction;

  • Excellent writing skills;

  • Interest in bioinformatics;

  • Team player.

This job comes from a partnership with Science Magazine and Euraxess