A postdoctoral position is available for an enthusiastic molecular and cellular neurobiologist interested in investigating Neuregulin (NRG)\ErbB4 signaling pathways in the Section on Molecular Neurobiology. Neuregulin (NRG)\ErbB4 signaling pathways is genetically associated with schizophrenia and bipolar disorder which regulates synaptic properties and neuronal networks that underlie cognitive functions altered in psychiatric disorders.
We are recruiting for a motivated molecular and cellular neurobiologist to assist with our goal of understanding the mechanisms that govern NRG processing and their differential functions that ultimately contribute to altered behaviors associated with cognition. Our recent studies discovered that, depending on protein secondary structure, distinct members of the NRG family are trafficked differentially to either neuronal soma or axons. Unprocessed single-transmembrane proNRG isoforms are targeted to soma and accumulate atop of subsurface cisternae (specialized extensions of endoplasmic reticulum), where they are processed and released in an activity-dependent fashion. By contrast, dual-transmembrane NRGs are processed by BACE1 in the Golgi and trafficked to axons. Lab at the Porter Neuroscience Research Center: https://www.nih.gov/about-nih/john-edward-porter-neuroscience-research-center
Requirements: a PhD or MD/PhD in neuroscience, molecular biology and biochemistry
Please send applications including a curriculum vitae, a statement of research interests and long-term career goals, and the name, email and mailing addresses of three references by August 31, 2017 to: Dr. Andres Buonanno, Section on Molecular Neurobiology, Porter Neuroscience Research Center, Building 35 Rm 2C-1000, Bethesda, MD 20892. (email@example.com).
HHS, NIH, and NICHD are Equal Opportunity Employers