PhD position (DNA Demethylation and Development): Developmental Epigenetics in Xenopus Embryos

IMB Mainz
May 31 2017
Life Sciences, Biology
Position Type
Full Time
Organization Type

In the field of DNA Demethylation and development”, the research group of Prof. Dr Christof Niehrs offers the following PhD projects:

Developmental epigenetics in Xenopus embryos


In this project we will carry out a screen for novel epigenetic and demethylation regulators in Xenopus (frog) embryos, where microinjection yields facile access to functional analysis of gene function. We will misexpress candidate epigenetic regulators by mRNA overexpression and antisense Morpholino injection to score for interesting developmental phenotypes. Candidate genes will then be studied by next generation sequencing, including genome-wide gene expression (RNA-seq) to monitor marker gene expression changes and DNA methylation (bisulfite-seq) analysis.  Further characterization of changes in embryonic gene expression will be followed up by genome wide ChIP-seq and bioinformatics analysis.  We will employ a systems biology approach for the understanding of the candidates gene function.  


We offer

  • The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team

  • A stimulating, diverse and international research environment

  • Advanced training opportunities

  • A fully funded PhD position


Duration of stipend/salary: 3 years, with the possibility of extension

Starting date: 1 March 2018 or later

Deadline for registration (exclusively online via web form): 15 November 2017


For further questions and contact information please check our website:


Please apply exclusively via our online form at:



This job comes from a partnership with Science Magazine and Euraxess

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