The project Predictive Biomarkers of Radiation Toxicity (PBRTox) of the Foundation for Polish Science is funded by the Intelligent Development Operational Programme of the European Union.
We are seeking a post-doc willing to work in an interdisciplinary team combining clinical medicine (radiation oncology), molecular biology and biostatistics/bioinformatics.Project's outline:
Radiotherapy (RTx) is the mainstay of oncologic treatment. Interruptions of its course due to adverse effect markedly increase the probability of recurrence and death. Prediction of radiation-induced adverse effects is thus of crucial importance as is allows the doctors to tailor the treatment and provide supportive care to those in need. We will investigate whether a serum-borne family of biomarkers - microRNAs - can be used as biomarkers of adverse effects in patients with head&neck cancers. Such individuals are group of oncologic patients with very high rates of such complications, putting them at serious risk of prognosis-altering RTx interruptions. Using a combination of clinical, laboratory and metaanalysis experiments we will propose an algorithm for RTx monitoring and identify biomarkers of radiotoxicity. Additionally, a systematic review and our own miRNA sequencing data will establish the subset of best reference miRNAs for studies on their expression in their serum.
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