Post-Doctoral Fellow in Cardiovascular Physiology and Pharmacology
Mechanisms of Excitation-Contraction Coupling in Vascular Smooth Muscle Cells
A post-doctoral fellow position (1st NIH echelon) is immediately available to work on a project to study the molecular mechanisms involved in the regulation of TMEM16A-encoded Ca2+-activated Cl- channels and TRP cation channels and their physiological and pathological functions in arterial smooth muscle cells and tissues, and in particular in pulmonary hypertension (Leblanc et al., Pulm Circ. 5:244-268). Techniques in the laboratory include patch clamp electrophysiology, epifluorescence and TIRF imaging, FRET, qRT-PCR, Western blotting, immunofluorescence, expression of ion channels and other proteins in mammalian cell lines, isometric force measurements in intact arterial tissue rings, and in vivo assessment of cardiovascular function in normal and transgenic mice using echocardiography and Doppler flow measurements.
The University of Nevada, Reno (established in 1874) is a national Tier 1 public university with an enrollment nearing 21,000 students. The city of Reno is located in the Great Basin Desert (elev. 4,500 feet) on the eastern side of the Sierra Nevada Mountain range, enjoying over 300 days of sunshine with temperatures in the summer time averaging 92oF. Reno is ~ 45 minutes away from beautiful Lake Tahoe (elev. 6,225 feet), the largest alpine lake in North America, and within 90 min from 18 ski resorts including Squaw Valley ski resort, the site of 1960 Winter Olympics. The Reno-Tahoe area is ideal for anyone enjoying outdoor activities such as mountain biking, hiking, camping, kayaking, golfing, fishing and hunting.
Experience with molecular biology, ion channel biochemistry, electrophysiology, and cardiovascular physiology preferred. Required qualifications include a Ph.D. or M.D. in Physiology, Biophysics or a related field. Send curriculum vitae and names and addresses of three references to Dr. Normand Leblanc, Professor, Department of Pharmacology/MS 318, University of Nevada, Reno School of Medicine, Manville Health Sciences Building, Room 9C, 1664 North Virginia St., Reno, Nevada 89557, USA (firstname.lastname@example.org;775-784-1420).