Senior Scientist – GpGx Early Discovery in Cardiometabolic Diseases Job

Boston, MA, US
June 02 2017
Organization Type
Senior Scientist – GpGx Early Discovery in Cardiometabolic Diseases:BIO004838


Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its 125-year legacy. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

The Genetics and Pharmacogenomics (GpGx) department at MRL is currently seeking a scientist with strong expertise in Human Genetics and Genomic bases of Cardiometabolic Diseases at MRL- Boston site. Our mission in GpGx is to identify and functionally validate novel targets anchored in Human Genetics that will enter Merck’s drug discovery pipeline for therapeutic intervention.

The Primary responsibilities of the candidate include:

- Integrate data from population-scale genetic cohorts as well as diverse types of genetic and non-genetic biomedical data including but not limited to eQTL, pQTL and Epigenome to identify causal Genetics Targets for Cardiometabolic Diseases.
- Formulate and initiate functional validation studies of Genetics Targets in collaboration with experimental scientists within and outside GpGx.
- Work with cross-functional teams including disease area biologists, pharmacologists and chemists for execution of the Genetics targets across early discovery pipeline.
- Strong collaboration and communication skills to interface effectively with wide range of subject matter experts in GpGx, Discovery, Clinical and External Communities



- PhD, MD or MD/PhD, preferably with 3+ years of academic or industry postdoctoral experience in genetics, cardiometabolic diseases or related fields.


- Proven track record and understanding of human genetics in disease areas including cardiorenal, diabetes, heart failure, fibrosis, ocular and/or other metabolic related diseases.
- Extensive experience in bioinformatics, statistical skills and ability to query databases to analyze large-scale genetic datasets as well as leveraging expression and epigenome database to generate hypothesis around potential causal gene.
- Strong understanding of clinical/pathobiology functional readout in cardiometabolic diseases for identifying translatable targets based on human genetics.
- Experience in translating Genetics Findings into functionalization of the target gene to provide insight into biological mechanism.
- Strong communication, collaboration, and leadership skills


- Background in statistical analysis of functional biology and/or pharmacogenomics.
- Insights into experimental biology and validation experiments with disease relevant in vitro and in vivo model systems.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. If you need an accommodation for the application process please email us at

Search Firm Representatives Please Read Carefully:

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

For more information about personal rights under Equal Employment Opportunity, visit:

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Primary Location: NA-US-MA-Boston

Job Type: Full Time

Employee Status: Regular

Travel: Yes, 5 % of the Time

Number of Openings: 1

Alternative Work Arrangements Available: Not Available

Relocation Provided: Domestic (within country)

Company Trade Name:Merck

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