Postdoctoral Fellow - Soranzo Faculty

Cambridge, Cambridgeshire
Salary £31,115 to £39,004 plus excellent benefits.
May 16 2017
Position Type
Full Time
Organization Type

Three years fixed term.

We are seeking to appoint a highly motivated post-doctoral research fellow in functional genomics for the Soranzo team ( at the Wellcome Trust Sanger Institute.

The group's primary research interest is to investigate the effect of genetic variation on human cardiometabolic phenotype, including quantitative organismal and molecular traits, combining statistical analyses and functional genomics approaches. We have recently revealed thousands of loci at high resolution for common and rare genetic variants which affect human blood cell development and function (Astle et al Cell2016 Nov 17;167(5):1415-1429). We have further used integration with large scale molecular phenotyping, including transcriptional and epigenetic states, to resolve molecular mechanisms at hundreds of genetic variants associated with immune disease (Chen et alCell2016 Nov 17;167(5):1398-1414).

We are now looking to recruit a Post-doctoral fellow in functional genomics / genomics scientist to work on new and exciting projects further elucidating the molecular mechanisms underpinning these observations. 

The post-holder's primary responsibility will be to deploy cutting-edge genomic analysis to perform large-scale functional screens to unravel causal mechanisms underpinning associations with human disease. Specifically, we wish to use techniques such as multi parallel reporter assays, genome engineering and single-cell transcriptomics to assay a molecular mechanisms to common and rare genetic variants identified through genome-wide scans. This project offers the opportunity to work in a multi-disciplinary team building upon recently published and diverse data sets with the potential to apply various genomics, genome editing or single cell transcriptomics technology to answer key questions affecting human biology. In addition, the post will benefit from the Sanger Institute’s capability for large-scale genomic scans, including platforms for cellular genetics. The successful applicant will work in close collaboration with computational scientists and have significant opportunities to develop and explore novel technologies in collaboration with other groups at the Institute.

Essential Skills

  • Postgraduate/Post-doctoral qualification in Molecular Biology and/or equivalent significant experience in a relevant area 
  • Track record of delivering complex scientific projects through to publication 
  • Ability to independently develop, assimilate and deploy research themes, as a member of a closely collaborative team 
  • Experience in mammalian cell culture including immortalised cell lines, primary cells and/or induced pluripotent stem cells 
  • Excellent organisation and record-keeping skills 
  • Ability to communicate effectively with team members and collaborators 
  • Experience and understanding of biological safety regulations and procedures 

Ideal Skills

  • Application of genome editing through CRISPR-Cas9
  • Experience in flow cytometry 
  • Experience in both wet-lab and dry-lab aspects of genomics methodologies, eg RNA-seq, ChIP-seq, ATAC-seq 
  • Working knowledge of blood cell biology 

Other information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 21th May 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.