Postdoctoral Position in Pediatrics/Cell Biology

Dr. Perlmutter, Dean of the School of Medicine, and Dr. Rudnick
Saint Louis, Missouri
Salary is commensurate with experience
April 25 2017
Position Type
Full Time
Organization Type
Job Type

A postdoctoral fellow position is available in the laboratory of Drs. Perlmutter and Rudnick at Washington University School of Medicine.  Our labs work together on the molecular and cellular mechanisms of liver disease in α1-antitrypsin deficiency, a genetic disease characterized by intracellular accumulation of a misfolded secretory protein.  Most of the work in our labs currently focuses on elucidation of the mechanisms by which the misfolded α1-antitrypsin variant is degraded by cellular pathways, including autophagy and the proteasome.  We also work on proteostasis signaling mechanisms by which cells adapt to the accumulation of misfolded proteins and we are currently working on the roles of insulin and NFκB signaling pathways specifically.  Another area of research is drugs which reduce the cellular load of misfolded proteins by stimulating autophagy or other proteostasis targets and benefits from work in the laboratories of our collaborators using a C. elegans model and high-throughput screening platforms. The investigator filling this position will carry out experimental work using cellular biochemistry and protein chemistry techniques in existing animal and cell model systems and develop new model systems using genomic engineering.

Interested candidates with a PhD, MD or MD- PhD and a strong background in  molecular biology, tissue culture, protein chemistry and bioinformatics, please email a single PDF file that includes a cover letter, CV and the names of 2 referees to Dr. David Rudnick MD-PhD, Assistant Professor, Washington University in St Louis at

Washington University is an Equal Opportunity Employer.  All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.

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