Postdoctoral Fellow or Experienced Scientist in Stem Cells and Epigenetics at University of Michigan
Our group at the University of Michigan is seeking a postdoctoral candidate and/or experienced scientist who is self-motivated and career-oriented to work in the areas of retinal/neural development, chromatin biology, and eye cancers.
The focus of the lab is stem cell biology and epigenetics. Since eye diseases are the first human disorders for which clinical trials for embryonic and induced pluripotent stem cell-derived tissue transplantation are being conducted, you will be at the cutting edge of a technology important for regenerative medicine.
The projects include, but not limited to:
1) derivation of clinically relevant cell types such as photoreceptors from mouse and human pluripotent stem cells,
2) how perturbation of chromatin modifications affect genome-wide enhancer localization, stem cell differentiation to retinal cells in vitro and in mouse models using gene editing (CRISPR/Cas9) and pharmacological inhibitors developed in the lab; and
3) epigenetic targeting of cancer stem cells (retinoblastoma) through use of cell lines, and primary human tumor tissue.
- Doctoral degree in biological science (PhD or MD).
- Highly motivated, detail oriented, responsible individual with excellent communication and organizational skills.
- Ability to work and troubleshoot independently.
- Must be proficient in Microsoft Office, Prism, and Adobe software, and knowledge of or capable of learning basic bioinformatics techniques.
- Previous laboratory experience (1 to 3 years) with strong molecular biology and stem cell experimental background (e.g. mouse or human ES cell culture, mouse genotyping, western blotting, protein immunoprecipitation, PCR, RNA interference, flow cytometry, bacterial and mammalian protein expression, and purification, viral transduction, electroporation, cloning, CRISPR/Cas9.
- The qualified candidate will have earned a doctoral degree in the biological sciences, specificially stem cells, epigenetics, bioinformatics, or a closely related field.
- Desired, but not necessary: Ability to work with/programming in R, Python, next generation sequencing analysis, other bioinformatics techniques.
- The candidate must provide proof of U.S. citizenship or current eligibility to work in the United States, and be available on or before June 15, 2017 in order to apply.
- Please send names of 3 referees, and a CV with evidence of strong track record with one or several first author research paper in a peer-reviewed journal. Expertise in the techniques mentioned above is a strong plus.
The University of Michigan and the Ann Arbor area is a great place to work and live.
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