PhD Scientist - Immunology

Cambridge, Massachusetts
March 13 2017
Position Type
Full Time


Vedanta BioSciences

Company Overview

Vedanta is pioneering the development of a new class of therapies that act by modulating the human microbiome. Modulation of the human microbiota holds enormous promise to treat a broad range of immune, infectious, and metabolic diseases in ways that are completely different to existing drug classes. Breakthrough discoveries of our scientific team in the field of mucosal immunology have led to the first rationally designed drug candidates in the microbiome field. Vedanta was founded by PureTech Ventures and a team of world renowned experts in immunology and microbiology.

Position Description / Responsibilities

The Ph.D. will conduct in-vivo studies designed to assess the ability of commensal bacteria to induce immune responses in germ-free and conventional mice. The principal activities of this role will be to develop assays to evaluate molecular and cellular pathways of host-microbe interactions, execute high-throughput screens, and perform in vivo experimental procedures using mouse models. Responsibilities also include the culturing and phenotypic characterization of human and murine primary immune cells.  The job title and level will correspond to the experience and skills of the selected candidate. 


  • Ph.D. in immunology with a focus on mucosal immunotherapy and the role of the microbiome. Research experience in autoimmunity and/or gastrointestinal inflammatory diseases a plus
  • Expertise in the use of germ -free mice as well as animal models of gut associated autoimmunity and inflammation desired 
  • Previous research experience and basic immunological techniques (flow cytometry, ELISA, cell culture and phenotypic characterization of primary immune cells) as well as molecular biology methods (RNA and DNA isolation and analysis, PCR)
  • Highly motivated and organized individual with excellent communication skills
  • Strong publication record
  • Team player, able to work well in a group setting as well as independently in a fast paced environment.
  • General understanding of the field of the human microbiome is preferred but not required.