The INSERM Cardiovascular Epidemiology and Sudden death unit, from the Paris Cardiovascular Resea...

March 01 2017
Life Sciences, Biology
Position Type
Full Time
Organization Type

The project: To address several hypotheses underlying the association between depression and incident cardiovascular disease. Hypotheses cover the psychosocial area, sleep complaints, arterial stiffness, heart rate variability, baroreflex sensitivity and circulating biomarkers. The project is based on the Paris Prospective Study III, an ongoing observational prospective cohort of 10 000 participants

1)Gaye B, Mustafic H, Laurent S, Perier MC, Thomas F, Guibout C, Tafflet M, Pannier B, Boutouyrie P, Jouven X, Empana JP. Ideal Cardiovascular Health and Subclinical Markers of Carotid Structure and Function: The Paris Prospective Study III. Arterioscler Thromb Vasc Biol 2016; 36:2115-24.

2)Gaye B, Prugger C, Perrier MC, Thomas F, Plichart M, Guibout C, Lemogne C, Pannier B, Boutouyrie P, Jouven X, Empana JP. High level of depressive symptoms as a barrier to reach an ideal cardiovascular health. The Paris Prospective Study III. Sci Rep 2016;6: 18951

3)Empana JP, Prugger C, Thomas F, Perier MC, Zanoli L, Castiglioni P, Guibout C, Causeret S, Barnes C, Lemogne C, Parati G, Laurent S, Pannier B, Boutouyrie P, Jouven X. Serotonin and norepinephrine reuptake inhibitors antidepressant use is related to lower baroreflex sensitivity independently of the severity of depressive symptoms. A community-study of 9213 participants from the Paris Prospective Study III. Atherosclerosis 2016;251:55-62

4)Empana JP, Perier MC, Singh-Manoux A, Gaye B, Thomas F, Prugger C, Plichart M, Wiernik E, Guibout C, Lemogne C, Pannier B, Boutouyrie P, Jouven X. Cross- sectional analysis of deprivation and ideal cardiovascular health in the Paris Prospective Study 3. Heart 2016 [Epub ahead of print]

5)Péquignot R, Dufouil C, Prugger C, Pérès K, Artero S, Tzourio C, Empana JP. High Level of Depressive Symptoms at Repeated Study Visits and Risk of Coronary Heart Disease and Stroke over 10 Years in Older Adults: The Three-City Study. J Am Geriatr Soc 2016;64(1):118-25

6)Carcaillon L, Plichart M, Zureik M, Rouaud O, Majed B, Ritchie K, Tzourio C, Dartigues JF, Empana JP. Carotid plaque as a predictor of dementia in older adults: the Three-City Study. Alzheimers Dement. 2015 Mar;11(3):239-48

7)Majed B, Arveiler D, Bingham A, Ferrieres J, Ruidavets JB, Montaye M, Appleton K, Haas B, Kee F, Amouyel P, Ducimetiere P, Empana JP; PRIME Study Group. Depressive symptoms, a time-dependent risk factor for coronary heart disease and stroke in middle-aged men: the PRIME Study. Stroke 2012;43(7):1761-7.

8)Prugger C, Luc G, Haas B, Arveiler D, Machez E, Ferrieres J, Ruidavets JB, Bingham A, Montaye M, Amouyel P, Yarnell J, Kee F, Ducimetiere P, Empana JP; PRIME Study Group. Adipocytokines and the risk of ischemic stroke: the PRIME Study. Ann Neurol. 2012 Apr;71(4):478-86....

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