Postdoctoral Fellow

Location
San Diego, California
Salary
Commensurate with NIH guidelines based on experience
Posted
November 07 2016
Position Type
Full Time
Job Type
Postdoc

Our laboratory investigates the genetic regulators of tissue development, differentiation, and homeostasis using the human epidermis as a model system. We investigate candidate protein and noncoding genetic elements in primary human epidermal cells, reconstituted organotypic human epidermis, and xenografted skin models. Our techniques include genome engineering (CRISPR/Cas9) gain/loss-of-function and mutagenesis, as well as whole transcriptome and proteome analysis. From the bedside, we obtain patient samples of uncommon or mosaic skin diseases and use next-generation sequencing to identify causative gene candidates. We investigate these variants using our model systems to develop a comprehensive molecular understanding of the pathogenesis of human epithelial diseases.

This postdoctoral fellowship offers the opportunity to develop a unique niche in investigating genetic elements required for epithelial tissue development and disease using primary human cells and tissue models. Candidates with an interest in studying scientific questions with a focus on human disease will find excellent opportunities to develop projects that are closely linked from bedside-to-bench.