Post-doc position (Department of Mitochondrial Physiology)

Institute of Physiology CAS
Czech Republic
November 03 2016
Life Sciences, Biology
Position Type
Full Time
The research subject will include studies of proteins essential for redox regulations during glucose-stimulated insulin secretion (GSIS), determination of their contribution to the type 2 diabetic etiology when impaired. Molecular biology studies will be performed with insulinoma INS1E cells or beta cells sorted from the accutase-digested Langerhans islets. Diabetology studies will include glucose-tolerance tests, tests of various secretagogues or GSIS potentiation by GLP-1. Beta-cell-specific transcription factors will be also studied. The role of mitochondria-morphology-shaping proteins will be elucidated. Overall, we'll determine which proteins are essential for redox regulations during GSIS and relate new findings to the possible development of glucotoxicity- and lipotoxicity- related oxidative stress initiating type-2 diabetes.

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