Self-renewal and differentiation in intestinal stem cells (PIN_F17DTP1)

University of East Anglia
October 31 2016
Position Type
Full Time
We invite applications for a PhD studentship to work with the teams of Dr Carmen Pin at Institute of Food Research, Norwich, and Prof Alastair Watson from the Norwich School of Medicine of the University of East Anglia.

The intestinal epithelium is formed by a continuous monolayer of epithelial cells with crypts or invaginations into the mucosa and in the small intestine protrusions or villi towards the lumen. Intestinal stem cells are located at the base of the crypts and they are the driving force behind the continuous renewal of the intestinal epithelium. Recent experimental research has generated fundamental insight into the biology of stem cells during homeostasis. However, it has also revealed important questions concerning their proliferation and ability to replace each other. The purpose of this project is to integrate analytical and computational models with experimental work to advance our understanding of the behaviour of the stem cell population in a healthy GI tract and help to quantify loss of homeostasis in disease.

Successful candidate profiles for this multidisciplinary project include formal training in Biology, BioMedicine, Biomathematics, Biophysics, Bioengineering with an interest in mathematics or computing science. Likewise, numerical trained candidates, such as Physicists, with an interest in stem cell or gut Biology are also invited to apply.

This project has been shortlisted for funding by the Norwich Biosciences Doctoral Training Partnership (NRPDTP). Shortlisted applicants will be interviewed as part of the studentship competition. Candidates will be interviewed on either the 10th, 11th or 12th January 2017.

The Norwich Biosciences Doctoral Training Partnership (NRPDTP) offers postgraduates the opportunity to undertake a 4 year research project whilst enhancing professional development and research skills through a comprehensive training programme. You will join a vibrant community of world-leading researchers. All NRPDTP students undertake a three month professional internship (PIPS) during their study. The internship offers exciting and invaluable work experience designed to enhance professional development. Full support and advice will be provided by our Professional Internship team. Students with, or expecting to attain, at least an upper second class honours degree, or equivalent, are invited to apply.

For further information and to apply, please visit our website:

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