Postdoctoral scholarships in Medicinal Chemistry & Systems Biology of human disease

Location
Sweden
Salary
The scholarship covers a period of 12 months with possibility of prolongation up to a maximum of 24
Posted
October 20 2016
Ref
E2016/593
Position Type
Full Time

Postdoctoral scholarship in Medicinal Chemistry

Mardinoglu lab at SciLifeLab develop Genome-scale metabolic models (GEMs) for human cells/tissues and employ these comprehensive models in the analysis of the omics data obtained from subjects with complex diseases including obesity, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D) and certain types of cancer (e.g. Hepatocellular Carcinoma). This is an exciting area of biomedical research, driven by the increase of common metabolic disorders as well as recent discoveries of metabolic reprogramming in cancer. The target kinase has been identified by the Mardinoglu group using Systems Biology and the candidate will be working on the development of the inhibitors targeting this specific kinase.

The Grøtli lab focus on the use of synthetic organic chemistry to produce novel compounds for the study of complex cellular pathways in cell biology and medicine. Such compounds are interesting both as potential therapeutics and as experimental tools for understanding the physiological roles of the target proteins. Two types of compounds are of special interest: probes for visualization (e.g. fluorescence-based sensors for detection of enzymatic activity in vivo and in vitro; fluorescent-nucleic acid base analogues), and probes for selective perturbation of biological processes (e.g. kinase inhibitors).

The successful candidate will focus on the development of novel routes for synthesis of potential kinase inhibitors identified by computer-based design and biological testing. The project will be carried out at Department of Chemistry and Molecular Biology, University of Gothenburg (UGOT) under supervision of Prof. Morten Grøtli (UGOT) and Ass. Prof. Adil Mardinoglu (KTH). The project will provide an opportunity to practice cutting edge medicinal chemistry in an interdisciplinary context that directly impacts the discovery of new therapeutics.

Qualifications:

  • The successful postdoctoral applicant should have significant and documented experience in synthetic organic chemistry, and preferably experience from medicinal chemistry. In addition, the candidate must be self-motivated and able to work independently but also to work efficiently in a team setting.
  • To be eligible for a post-doc scholarship at the recipient must hold a PhD degree within a relevant field. The applicant must not have been employed at University of Gothenburg in the past two years.

Written application, including reference number, is to be sent via e-mail to the Prof. Grøtli (grotli@chem.gu.se) and must include the following:

  1. CV
  2. Personal letter stating the reasons why the study suits the applicant (maximum one page)
  3. List of publications
  4. Contact information for two references

Application deadline: December 15, 2016

Start date: According to agreement, as soon as possible is desirable

Scholarship period: The scholarship covers a period of 12 months with possibility of prolongation up to a maximum of 24 months in total.

Supervisors/contact persons: Prof. Grøtli (grotli@chem.gu.se);

 

Postdoctoral scholarship in Systems Biology of human disease

Mardinoglu lab at SciLifeLab also seeks for Postdoctoral fellow in Systems Biology of human disease. Systems biology is an interdisciplinary subject where the systems of biological components are studied using mathematical models, computational models and experimental technologies such as genomics, proteomics, transcriptomics and metabolomics. It includes application and development of systems biological methods with particular emphasis on integration, analysis and modelling of big data within the field of molecular biosciences.

We are now seeking one postdoc with strong computational skills to integrate the GEMs with other biological networks including regulatory, signalling and protein-protein interactions (PPIs) networks. The candidates will use these integrated networks in the analysis of the omics data obtained from different clinical conditions to identify drug targets and discover biomarker for the development of the efficient treatment strategies. The candidates will be working with closely collaborated the experimental groups as well as number of big pharma companies.

Qualifications

The candidates are expected to perform research in Systems Biology, Systems Medicine, Network Medicine and Bioinformatics. We are therefore seeking for two highly motivated individuals with a PhD in Computational Biology (degree must have been completed no more than five years before the application deadline), and a strong publication record. A MD is meritorious.

The candidates should also have a strong background in applied mathematics and bioinformatics, especially in network models / graph theory and analysis of the Next-generation sequencing data. The candidates should also be adept at programming numerical algorithms in languages such as MatLab, R and Python.

The candidates should be highly motivated for doing scientific research related to human diseases and should have well developed analytical and problem solving skills. Additionally

Application

Written application is to be sent via e-mail to the Ass. Prof. Mardinoglu (adilm@scilifelab.se) and must include the following:

  1. CV
  2. Personal letter stating the reasons why the study suits the applicant (maximum one page)
  3. List of publications
  4. Contact information for two references

Application deadline: December 15, 2016

Start date: According to agreement, as soon as possible is desirable

Scholarship period: The scholarship covers a period of 12 months with possibility of prolongation up to a maximum of 24 months in total.

Supervisors/contact persons: Ass. Prof. Mardinoglu (adilm@scilifelab.se)