Post Doctoral Position in Stem Cells and Epigenetics at University of Michigan
We are seeking an experienced postdoctoral research fellow who is energetic, enthusiastic, and enjoys collaborative and independent science.
The focus of the lab is stem cell biology and epigenetics. Since eye diseases are the first human disorders for which clinical trials for embryonic and induced pluripotent stem cell-derived tissue transplantation are being conducted, you will be at the cutting edge of a technology important for regenerative medicine.
Successful candidates will become part of a highly successful and collaborative team of junior and senior investigators in state of the art, interconnected laboratory space. Within the group, there is a strong commitment to mentorship and an excellent track record of success for both academic and industrial-career track oriented individuals.
Duties for this position include interdisciplinary interactions with the Departments of Ophthalmology and Pathology as well as:
- Molecular biology experiments (genetics, epigenetics, proteomics). Cloning, protein purification, gene editing (CRISPR/Cas9), chromatin immunoprecipitation and RNA-seq.
- Cell culture techniques: mouse and human embryonic stem cell maintenance and differentiation to eye/neural tissues, derivation of human and mouse induced pluripotent cell lines, retinal slice culture assays of viability using novel small molecule epigenetic compounds.
- Handling and managing animals: transgenic mice (Cre/flox), colony management, dissection, sectioning, PCR, ISH and IHC.
- Preparation of biological and chemical reagents and cell lines, including transduction with viral vectors, transfection, electroporation, etc
- Ordering and maintaining lab supplies.
- Maintaining compliance.
- Doctoral degree in biological science (PhD or MD).
- Highly motivated, detail oriented, responsible individual with excellent communication and organizational skills.
- Ability to work and troubleshoot independently.
- Must be proficient in Microsoft Office, Prism, and Adobe software, and knowledge of or capable of learning basic bioinformatics techniques.
- Previous laboratory experience (1 to 3 years) with strong molecular biology experimental background (e.g. mouse genotyping, western blotting, protein immunoprecipitation, PCR, RNA interference, flow cytometry, bacterial and mammalian protein expression, and purification)
The qualified candidate will have earned a doctoral degree in the biological sciences, bioinformatics, or a closely related field, must provide proof of U.S. citizenship or current eligibility to work in the United States, and be available on or before February 1, 2017 in order to apply.
- Ability to work with/programming in R, Python, next generation sequencing analysis, other bioinformatics techniques.
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