Marie Curie Postdoc position in Molecular Biology / Prostate Cancer

Employer
Fundación para la Investigación Biomédica de Córdoba (FIBICO)
Location
Spain
Posted
June 15 2016
Discipline
Other
Position Type
Full Time
The “Hormones and Cancer” group investigates the cellular and molecular principles underlying the development and progression of certain tumoral diseases and cancers and their associations with the endocrine-metabolic deregulations (obesity, metabolic syndrome); paying special attention to the role played by some neuropeptide systems such as somatostatin, cortistatin, ghrelin, their receptors and splicing variant, as well as the associated regulatory mechanisms. Specifically, our group has discovered and patented several cellular and molecular biomarkers, whose expression in tumoral tissues is linked to higher tumoral aggressiveness, and that could have significant implications in the development and progression of certain endocrine-related cancers. The final aim of the group is to identify novel diagnostic, prognostic and therapeutic biomarkers for tumoral and endocrine-metabolic pathologies.

Prostate cancer, an endocrine-related, heterogeneous and complex cancer that represents one of the most important threats for public health, is strongly influenced by the endocrine-metabolic alterations such as the obesity. However, despite the magnitude of these health problems and its associated costs, the molecular/cellular and endocrine-metabolic mechanisms underlying the pathological association between prostate cancer and obesity (i.e. increased incidence/aggressiveness/drug-resistance) are still unknown. In this context, the endocrine/metabolic regulatory systems comprised by somatostatin/cortistatin/ghrelin, their associated receptors/enzymes and their splicing variants (ligands/receptors), which are key regulators of whole-body homeostasis and are dysregulated in obesity and tumoral pathologies, represent promising common molecular targets in cancer and obesity. In this proposal, we will deploy a set of innovative clinical and experimental approaches, including numerous clinical samples and cellular/animal models, to: 1) characterize the presence and functional role of the systems comprised by somatostatin/cortistatin and ghrelin [ligands/receptors/enzymes and splicing variants (including the components of the splicing machinery)] and associated miRNAs in the development/progression and response to treatment of prostate cancer under normal and obesity conditions; and 2) to explore the efficacy and mechanism of action of drugs commonly used for the treatment of obesity or its comorbidities as novel therapeutic tools for the clinical management of prostate cancer and its interaction with obesity. The results generated could help to identify non-invasive biomarkers of early diagnostic/prognostic and response, whose final aim is to discover novel diagnostic and therapeutic biomarkers for these pathologies.

Applicants are invited to send a detailed CV and motivation letter before 15 July 2016 to jcarlos.prieto@imibic.org

This job comes from a partnership with Science Magazine and Euraxess

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