PhD Studentship in Bionformatics

Employer
RCSI Royal College of Surgeons in Ireland
Location
Europe
Posted
June 14 2016
Position Type
Full Time
Overall Purpose of this position


Breast cancer (BC) remains the most common form of malignancy in women with over 25% of all cancers being diagnosed as BC in 2012. In HER2-positive BC, which accounts for approximately 20% of all human BCs, HER2 gene amplification and overexpression is associated with an aggressive phenotype and poor prognosis. Trastuzumab, a monoclonal antibody targeted to HER2, has well established efficacy in the treatment of HER2-positive BC. However, a significant proportion of patients with the disease have tumours that initially do not respond or that acquire resistance to trastuzumab after an initial period of response. Few studies have been conducted to understand the role of innate resistance to trastuzumab. A thorough and integrative bioinformatics analysis of the transcriptome, genome and proteome of HER-positive BC patients is required to determine the underlying mechanisms driving this resistance. The advent of next generation sequencing (NGS) has allowed researchers access to the information stored in the genome. Within RCSI, we are in the enviable position of having access to extensive genomic, transcriptomic and proteomic patient datasets in HER2-positive BC along with detailed clinical information available from both Irish and international clinical trials. In addition, we also have access to large public ‘omics' datasets for HER-positive BC patients. The purpose of the PhD is to uncover the mechanisms driving resistance in HER2-positive breast cancer via the analysis of these complex datasets using off the shelf and novel bioinformatic approaches.

This job comes from a partnership with Science Magazine and Euraxess

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