A postdoctoral research position is available immediately in the laboratory of Megan McNerney, MD, PhD, in the Departments of Pathology and Pediatrics – Hematology/Oncology at The University of Chicago (https://mcnerneylab.uchicago.edu/). Research in the McNerney lab focuses on the genomics of therapy-related myeloid neoplasms and de novo acute myeloid leukemias (AML). A high-risk subset of patients are unresponsive to treatment and their survival is less than a year. Using genomic approaches, we identified the spectrum of mutations in these patients (McNerney, et al. 2013 Blood 121:975; McNerney, et al., 2014 Brit. J. Haematology, 66:550-556). We are now determining how these genetic changes alter transcriptional programs and networks to drive leukemogenesis, and how to target these pathways therapeutically.
Current projects focus on the function of the transcription factor CUX1, which we identified to be deleted or mutated in half of high-risk myeloid neoplasms. Methods in the lab include functional genomics (such as ChIP-seq, RNA-seq, etc.), in vivo mouse models, and work with primary patient samples. These studies are being performed within the rich scientific environment at The University of Chicago. The McNerney lab collaborates with colleagues in the Departments of Pathology, Medicine-Hematology/Oncology, the Institute for Genomics and Systems Biology, and the NCI-designated Comprehensive Cancer Center. There are seminars, journal clubs, retreats, and other opportunities for intellectual interactions.
The successful applicant will have the opportunity to guide functional genomic research determining how CUX1 controls gene expression, genomic architecture, and chromatin remodeling during development and in leukemogenesis. Inquiries are welcome from pending and recent PhD and/or MD graduates who have a strong record of research accomplishment during their predoctoral years. Commitment to research and enthusiasm for discovery are essential, but candidates should have expertise in one or more of the relevant fields, including computational biology, bioinformatics, molecular biology, human genetics, or related disciplines. Experience in hematology, cancer biology, or mouse model experimentation is a plus.
Applications, including a letter describing your research experience and interests, future career aspirations, your CV, and contact information for three references, or informal inquiries should be emailed directly to Megan McNerney (email@example.com).
The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national or ethnic origin, age, status as an individual with a disability, protected veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination at http://www.uchicago.edu/about/non_discrimination_statement/. Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-5671 or email ACOppAdministrator@uchicago.edu with their request.