PhD Position, Biological Sciences, Strasbourg

Employer
CERBM (IGBMC)
Location
France
Posted
June 03 2016
Position Type
Full Time
The aim of the PhD project is to decipher the relationship between phosphoinositides and related proteins mutated in myopathies, their roles in muscle, and to validate therapeutic proof-of-concept to balance this pathway in myopathies.

1) Role of phosphoinositides in muscle. Impact of this pathway on the formation, maintenance, dynamic and function of muscle-specific membrane structures will be investigated in an in vitro muscle differentiation system and in vivo in mice with biochemistry, immunolabeling and confocal and live imaging.

2) Implication of phosphoinositides in myopathies. Mice models reproducing myopathies are already available in the lab and will be used to assess the importance of phosphoinositides in the pathology through cell culture, histology, imaging and animal phenotyping.

3) Modulation of this pathway to treat myopathies in mice. Using our mice models and the knowledge obtained from the other tasks, therapeutic proof-of-principle will be conceived and validated, through gene modulation and pharmacology.

This project will decipher the role of phosphoinositides in the pathophysiology of these diseases, and their therapeutic potential. This project at the Department of Translational Medecine (IGBMC, Strasbourg) is funded for 3 years including a competitive PhD salary, as part of the Marie Sklodowska-Curie European Innovative Training Network “Deciphering PI3K biology in health and disease” (http://pi3k-phdproject.eu). The consortium includes ten partners from UK, France, Germany, Switzerland, Italy and Spain, and will train PhD students in in vitro and in vivo approaches for the analysis of physiological processes to pathological situations. The recruited student will benefit from interactions with other members of the consortium through joint research training, scientific collaborations and participation in project meetings. The student selected will learn cell culture, intravital and confocal imaging, pathophysiology in mouse models, viral gene transfer, drug therapy, management of a research project (choice of strategies, experiments, analysis and validation), oral (meetings, congress) and written (publications, posters) communications, and will participate to the writing of publications.

This job comes from a partnership with Science Magazine and Euraxess