Post-doctoral researcher (cancer stem cells)

Employer
Institut d'Investigació Biomèdica de Girona (IDIBGI)
Location
Spain
Posted
May 24 2016
Discipline
Other
Position Type
Full Time
The Metabolism & Cancer Group led by Dr. Menendez within the Girona Biomedical Research Institute (IDIBGI) as part of the Program against Cancer Resistance (ProCURE)-Catalan Institute of Oncology (ICO), is an internationally-recognized group with strong expertise on cancer metabolism that aims to integrate not only biologists, biochemists, and pharmacists, but also oncologists, radio-oncologists, and pathologists. The current project will be developed within the IDIBGI research capabilities in its new headquarters at the Martí & Julià Hospital Park in Salt (Girona, Spain), where the proposal aims to integrate Dr. Menendez's broad experience in onco-molecular medicine with an infrastructure capable of supporting a wide range of basic, translational, and clinical research.



The Metabolism & Cancer group is now starting a restaffing process to recruit very talented postdoctoral researchers feeling passionate to investigate the mechanisms causally linking metabolism to the emergence of the so-called cancer stem cells (CSC), resulting in the origin of a new-dimensional cancer hallmark called “metabostemness”. The candidate will be involved in an exciting new project aimed to characterize theunique metabolic dependencies that are required not only for specific CSC bioenergetic/biosynthetic demands but also for sustaining the operational epigenetic properties of CSC, i.e. self-renewal, tumor-initiation, and plasticity. The project goal is to demonstrate that the metabolic features and dependencies of CSC states provide a built-in “metabolic barcode” that can be used to detect and monitor CSC functioning which, in turn, should significantly improve our ability to examine changes in CSC-driven tumor cell populations for cancer detection, prognosis, prediction/monitoring of therapy response, and detection of therapy resistance and of recurrent disease.We are particularly interested in therapeutically exploiting the vulnerability of the underexplored framework linking metabolism & epigenetics with CSC functioning during cancer relapse and metastasisin breast, lung, and colon cancer.



The successful candidate will have a PhD with extensive experience in cancer biology. The candidate must be skilled in various laboratory research techniques including molecular biology, cell culture (ES and iPS cells, organoid cultures), genome editing techniques, establishment and passaging of patient tumour xenografts via various injection routes, tissue harvest/processing, and immunohistochemical techniques.



The funds for this post are available for 2 years in the first instance.

This job comes from a partnership with Science Magazine and Euraxess

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