Postdoctoral researcher to study peroxisomal function in the endocrine pancreas

KU Leuven
May 24 2016
Position Type
Full Time
The Lab of Cell Metabolism is part of the Department of Pharmaceutical and Pharmacological Sciences. Our primary objectives are 1) to understand the role of peroxisomes and in particular of peroxisomal β-oxidation in diverse tissues and during different stages of life 2) to investigate the pathological mechanisms in peroxisomal diseases which should allow the development of therapies. To approach these questions we were among the first to generate mouse models for peroxisomal disorders and continued with the generation and characterization of conditional knockout mice with cell type selective deletion of peroxisomal proteins. During the last 2 decades, we have gathered a broad expertise in phenotyping and handling of mouse models with peroxisome deficiencies.

Recently, we obtained intriguing preliminary data that glucose homeostasis is disturbed in a mouse model with pancreatic beta-cell selective inactivation of peroxisomal function.

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- Perform  in vitro research focused on peroxisomal function in pancreatic beta-cells

- Perform in vivo and ex vivo research on mouse models with peroxisomal deficiencies in beta-cells.

This job comes from a partnership with Science Magazine and Euraxess

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