Postdoctoral Fellow - Senior Bioinformatician
Salary range: £30655 to £38428pa plus excellent benefits
Fixed-term for 3 years
We are looking for a creative, motivated and collaborative bioinformatician/postdoctoral scientist to join the Host-Microbiota Interactions Laboratory (www.lawleylab.com) investigating interactions between host and microbiota during health and disease. The group has projects focused on infectious diseases, antibiotic therapies, autoimmune diseases and early life colonization. The lab is very collaborative and consists of microbiologists, bioinformaticians, cell biologists and mouse biologists so there is ample capacity for the individual to develop new skill sets. The group is well resourced giving the individual access to cutting edge genomic and proteomic tools (host and microbiota), human organoids, transgenic mice, germ free mice, a human microbiota bacterial culture collection and state of the art anaerobic culturing facility. The lab is focused on translational science with links to the biotech industry.
The Lawley Lab has developed unique capabilities to culture the majority of bacteria in the human intestinal microbiota (Browne et al. 2016. Nature). The Lab maintains an extensive bacterial culture collection of >300 species and has sequenced all species to generate reference genome database (Forster et al. 2016. NAR). The individual will use advanced genomic analysis methods and generally focus on establishing the phylogenies and accessory genomes of dominant bacterial clades the human intestinal microbiota to assist in identifying functional attributes of bacteria that promote health. This is a unique position as the project leverages a comprehensive human microbiota culture collection and associated genomic data combined with cutting edge laboratory culturing and animal model facilities in a world leading genome research institute.
The applicant should have a strong background in bioinformatics, a knowledge of microbiology and have an interest in learning about host-pathogen interactions and the biology of host-associated microbial communities during health and disease.
Key Responsibilities include:
- Manage and analyse large-scale whole-genome sequencing datasets and their associated projects
- Perform analysis on datasets generated by next generation sequencing platforms
- Integrate sequence data with biological experiments/phenotypic data
- Liaise with collaborators and coordinate projects
- Train group members
- Develop software and develop new methods to analyse sequence date
- PhD or MSc in microbiology, population genetics, molecular evolution, computer science, mathematics or bioinformatics
- Ability to program in either Perl or Python, or in C/C++ or Java
- Experience with bacterial genomics, genome annotation, phylogeny and metagenomics
- Expertise in data modelling, machine learning, statistical analysis and associated approaches
- Outstanding personal initiative and communication skills
- Strong publication record in peer-reviewed journals
- A desire to learn, to innovate and to move out of their comfort zone
- Experience working with next generation sequence data and/or large datasets
- Ability to communicate with collaborators across a broad range of fields
- Ability to work under time pressure and to tight deadlines
- A degree in a relevant biological subject (genetics, biochemistry)
- Ability to lead and drive research projects
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. The post is a three year fixed-term contract.
The Sanger Institute is a charitably funded research centre that applies the power of genomics to uncover the basis of genetic and infectious disease. We conduct science at a scale and speed that sets our research apart. Our passion is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.
The Institute is located near Cambridge on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.
To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.
Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.
Closing date: 1st June 2016