Postdoctoral Fellow | Post Doc in Tissue Regeneration at the University of Pennsylvania

University of Pennsylvania
Philadelphia, Pennsylvania (US)
NIH scale + benefits, adjusted based on experience
April 06 2016
Position Type
Full Time

The laboratory of Thomas Leung at the University of Pennsylvania ( is inviting applications for a postdoctoral researcher.

Our group studies how injured tissues heal, and in some cases, how injured tissues regenerate without a scar. We have innovated new methods for studying these processes in mice and humans, and discovered cellular, molecular, and genetic mechanisms governing inflammation, wound healing, and tissue regeneration. Based on our findings, we have several active clinical trials testing our conclusions in the clinic. As a practicing dermatologist, I try to use clinical observations to drive basic science discovery. An overarching goal of our work is to identify novel therapeutic strategies to improve healing (with or without scars) in humans.

We are seeking a qualified postdoctoral fellow with an interest in stem cells, inflammation, tissue regeneration, and regenerative medicine. The fellow will design and perform experiments using a variety of model systems (mouse, tissue culture, 3D human tissue culture) and techniques (molecular, biochemistry, genetic, histology, and genomics). An MD and/or PhD in a science-related field, excellent written and verbal communication skills, and the ability to work interactively are required.

Postdoctoral research in the lab commonly involves close interactions both within the lab and with collaborating groups at the University of Pennsylvania. Postdoctoral training includes participation in seminars and retreats of the Department of Dermatology and Institute of Regenerative Medicine. A major goal of our lab is to mentor and train fellows for future careers in academics and industry.

To apply, please email a letter of interest and a CV that includes three references to Dr. Leung ( Please include a statement about your interest in our lab and your career goals and objectives.

Select publications include:
Leung T.H., Snyder E.R., Liu Y., Wang J., and Kim S.K. (2015)
A cellular, molecular and pharmacological basis for appendage regeneration in mice.
Genes and Development. 29(20):2097-107. PMID: 26494786.
- Research Highlight: How mice regrow ear tissue. Nature 527: 136-137.

Sebastiano V., Zhen H.H., Derafshi B.H., Bashkirova E., Melo S., Wang P., Leung T.L., Siprashvili Z., Tichy A., Li J., Ameen M., Hawkins J., Lee S., Li L., Schwertschkow A., Bauer G., Lisowski L., Kay M.A., Kim S.K., Lane A.T., Wernig M., and Oro A.E. (2014)
Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa.
Science Translational Medicine. 26;6(264):264ra163. PMID: 25429056.

Leung T.H., Zhang L., Wang J., Ning S., Knox S., and Kim S.K. (2013)
Hypochlorite ameliorates NF-κB-mediated skin diseases.
The Journal of Clinical Investigation. 123(12):5361-70. PMID: 24231355.
- Covered by BBC news, Huffington Post, The Scientist, Reader's Digest, Allure, Daily Mail, Telegraph

Covert M.W.*, Leung T.H.*, Gaston J.E. and Baltimore D. (2005)
Achieving Stability of LPS-Induced NF-κB Activation.
Science. 309(5742): 1854-7. PMID: 16166516.
* These authors contributed equally to this work

Leung T.H., Hoffmann A., and Baltimore D. (2004) 
One nucleotide change in a kappa B site can determine cofactor specificity for NF-κB dimers.
Cell.  118(4): 453-64.  PMID: 15315758.

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