Experienced postdoctoral researcher interested in applying to a Marie Sklodowska-Curie Individual...

Centre Européen d'Etude du Diabète
March 23 2016
Position Type
Full Time
Free islet transplantation is considered as a promising therapy for patients with severe forms of type 1 diabetes (T1D). However, this technique faced two recurrent medical hindrances: organ shortage and low quality of transplants. Ischemia Reperfusion (IsR) related damages are partly responsible for the latter. Therefore, protection against IR is crucial in order to optimize islet transplantation. The challenge of this project is to prepare the donor's pancreas using ischemic preconditioning, and therefore obtain a better quality for islets. The project aims to develop and validate a clinically acceptable model of preconditioning, able to enhance islets survival and function, beneficial to graft success in diabetic rat. To this end, we are opting for an original interdisciplinary approach by combining islet isolation/transplantation with cutting-edge bioenergetics and metabolomics technologies. This project is intended to be quickly implemented on minipigs, with a final translation into clinical practice. The long-term goals of this study are to develop a therapeutic solution to pancreatic islets-transplant of T1D and likely to other organ transplantation.

This research program has already been submitted to the last MSCA-IF call (2015) and received a very high/encouraging rating (90.6/100, funding threshold: 93/100). In this respect, we are seeking an experienced researcher with excellent tack records who will be gradually in charge of the overall thematic. The MSCA-IF funding will provide a unique stepping-stone for the candidate's independent research career in Europe and successful collaborations in the future.

Required Experience: We are looking for collaborators with significant experience in bioenergetics (e.g. metabolism related to ischemia/reperfusion, mitochondrial biology, and oxidative stress) as well as a background in biological validation. Additional knowledge of late preclinical research stages (big animals, such as minipig) would be an asset.

The selected candidate will have to elaborate, together with the R&D supervisor and the grant manager a proposal to the MSCA-IF call for proposals.

Eligibility criteria:

- Experienced researcher (PhD holders, with postdoctoral experience) at any stage of your career, with a promising track record.

- Any nationality.

- You must not have resided or carried out the main activity (work, studies, etc.) in France for more than 12 months in the 3 years immediately prior to the call deadline (September 2016).

- Please see eligibility details here:


Expressions of Interest: Please send a CV with a track record (following the template provided by the European commission) and a short plan explaining how a Marie Sklodowska-Curie fellowshi

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