Engineering PSMA-targeted exosome-like vesicles to target prostate cancer metastasis (AL-JAMAL_U1...

University of East Anglia
March 22 2016
Position Type
Full Time
Prostate cancer is the second cause of death in men in the UK claiming about 10,000 lives every year. Clinical studies showed a range of effective anti-cancer drugs, however, their systemic toxicity has limited their clinical use. This PhD project will investigate a more effective way to treat prostate cancer by introducing new nanocarriers (exosome-based nanomedicine) to improve the therapeutic effects of existing anti-cancer drugs. These nanocarriers will target cancer cells that spread outside the prostate (metastatic tumour tissues). The scientific approach of this project is to engineer a novel exosome-based delivery system with high affinity to prostate cancer cells. Such approach is anticipated to improve drug delivery to target tissues, which ultimately increases therapeutic efficacy and reduces the associated side-effect. With the 3-year project, the PhD student will focus on engineering and characterizing the exosome-based delivery system, and assessing its therapeutic efficacy in vitro and in vivo animal models. This highly interdisciplinary project combines expertise in nanomedicine, drug delivery, targeting, and biology. It will provide a unique opportunity for excellent students to work in a stimulating multidisciplinary team.

The successful candidate will be a highly motivated, hard-working graduate holding a good honours degree and a master degree in Pharmaceutical sciences, biological sciences, or bioengineering. The candidate should have good experience with cell culture, biological assays, real-time PCR and western blot. Sound knowledge of prostate cancer, drug delivery, and analytical techniques for the characterisation of nanomaterials will be an advantage. The candidate will have excellent communication, presentation and organisational skills.

This job comes from a partnership with Science Magazine and Euraxess