NIH FUNDED POSTDOCTORAL POSITIONS
The Center for Vascular Biology at UConn Health is seeking two postdoctoral researchers to join collaborative translational research projects focused on 1) novel endocytic mechanisms regulating the inflammatory response to tissue injury and 2) the development of new therapeutic compounds targeting separate pathways to increase tumor cell death and reduce toxicity.
Project 1 will elucidate the molecular mechanisms of CD13 regulation of monocytic and endothelial function as it relates to inflammatory exacerbation of disease using a combination of in vitro cell culture and in vivo transgenic and knockout models of injury and disease. The CD13/APN cell surface peptidase is a potent regulator of cell motility, cell-cell interactions and endocytosis that typifies a novel class of modulators of both angiogenesis and inflammation.
Project 2 focuses on therapeutic targeting of cancer. We plan to evaluate new therapeutic compounds targeting separate pathways alone and in combination to determine those pathways that lead to improved tumor cell death and reduced toxicity. Experiments will use primary patient samples, in vitro cell culture, in vivo transgenic and xenograft cancer models.
Investigators in the Center for Vascular Biology have partnered with physician scientists in the Division of Pediatric Urology at Connecticut Children’s to advance our understanding and improve diagnosis and therapy for pediatric urologic diseases. Laboratories are located at the University of Connecticut Health Center (http://www.uchc.edu), a state of the art research facility with a diverse graduate/medical/dental program and an attractive campus centrally located between New York and Boston.
Requirements for these positions include: PhD, MD or equivalent; cell and molecular biology experience; proficiency in animal models/care and excellent written communication skills. Previous experience in tumor models or confocal imaging is strongly preferred but other relevant experience may suffice. Successful candidates will have recently completed their degrees (< 3 years) and have published in relevant journals.