Post-doc position

Employer
KULeuven - Endothelial Cell Biology Research Unit
Location
Europe
Posted
December 08 2015
Discipline
Life Sciences, Biology
Position Type
Full Time
The central project theme is related to endothelial heterogeneity. Endothelial cells lining the inside of arteries, veins, lymphatic vessels and capillaries in different organs have acquired specific molecular, morphologic and functional characteristics. Unraveling the mechanisms determining these vascular bed-specific characteristics offers the possibility to generate specific subsets of endothelial cells that can be applied for therapeutic or diagnostic purposes. We recently have compared endothelial signatures from different sets of endothelial cells, including arterial, venous and lymphatic endothelial cells and identified transcription factors that determine these signatures. While the role of Notch receptors and ligands has been documented in lymphatic endothelial cell (LEC) behavior, the role of the Notch target transcription factors remains unclear, partly because we found that their expression in LECs is to some extent Notch-independent. In this project we aim to understand the functional role of Notch target transcription factors in LECs in different lymphatic vascular beds in health and disease using models of lymphangiogenesis (e.g., wound healing and cancer) in transgenic mice.

This job comes from a partnership with Science Magazine and Euraxess

Similar jobs

Similar jobs