Brigham & Women's Hospital
About Brigham & Women's Hospital
Ai lab is within the Pulmonary and Critical Care division, Department of Medicine at Brigham and Women’s Hospital (BWH). The major research focus in Ai lab is the development and the function of the nervous system in the lung. Ai lab employs a combination of genetics, allergen models, and human lung slices/tissues to facilitate the discovery of the role of nerves in lung physiology and disease. Ai lab is the first to discover that members of the nerve growth factor family are required for lung innervation. Using genetic models deficient in these essential nerve growth factors, Ai lab has demonstrated a critical role of nerves in regulating the contractile phenotype of airway smooth muscle cells and pulmonary neuroendocrine secretion. Ai lab has developed a novel cryopreservation method for long-term preservation and later recovery of live human lung slices. This method opens exciting opportunities to study human airway and pulmonary vascular physiology and diseases in a meaningful, ex vivo system. Building upon the disease models and complementary research tools, Ai are actively pursuing how different types of nerves contribute to distinct disease phenotypes in the lung. Located in the Longwood Medical area in Boston, MA, Ai lab at BWH offer dynamic and exciting opportunities for career development. For Dr. Ai's profile at BWH, go to Harvard Catalyst at https://connects.catalyst.harvard.edu/Profiles/display/Person/132170.