At the NanoLSI center, we will combine the world’s most advanced technologies in bio-scanning probe microscopy (SPM) and supramolecular chemistry to develop novel “nanoendoscopic techniques” that allow us to directly image, analyze, and manipulate nanodynamics of proteins, metabolites, and nucleic acids both on the surface of and inside the cell. In addition, through the use of innovative nanoprobe techniques combined with other advanced analytical methods, we aim to achieve fundamental understandings of the nano-level mechanisms underlying basic cellular functions (e.g., cell differentiation/proliferation, stemness, signal transduction, genome dynamics, etc.) and their cancer-specific abnormalities. To this end, we will perform detailed comparisons between nanodynamics inside normal and cancer cells. Based on the developed technologies and knowledge acquired through such research works, we will establish a new research field termed “nanoprobe life science,” which aims to achieve nano-level understandings of various life phenomena including cancer using advanced nanoprobe technologies.