Springer Lab at BCH
- Website
- http://timothyspringer.org/
My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.
Our interests include:
- Integrins and how they communicate extracellular ligand binding to cytoskeleton assembly and force transduction
- cryoEM of integrin-ligand complexes (with Alan Brown)
- Single molecule studies of conformational change kinetics and force transmission (with TJ Ha)
- Transforming growth factor β and its localized activation at cell surfaces by integrins and proteases
- Stem cells and developmental pathways
- Nervous system development and microglia
- Tyrosine kinases and inside-out signals transmitted by them in transformed cancer cells
- Therapeutics development using deep biological insights into cell surface receptor conformational change
Get job alerts from Springer Lab at BCH straight to your inbox