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Springer Lab at BCH

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My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.

Our interests include:

  • Integrins and how they communicate extracellular ligand binding to cytoskeleton assembly and force transduction
  • cryoEM of integrin-ligand complexes (with Alan Brown)
  • Single molecule studies of conformational change kinetics and force transmission (with TJ Ha)
  • Transforming growth factor β and its localized activation at cell surfaces by integrins and proteases
  • Stem cells and developmental pathways
  • Nervous system development and microglia
  • Tyrosine kinases and inside-out signals transmitted by them in transformed cancer cells
  • Therapeutics development using deep biological insights into cell surface receptor conformational change

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