My lab studies receptor-ligand interactions and signal transmission across membranes. We use a wide range of structural, cell biological, and single molecule techniques to answer important questions relevant to immunology, hemostasis, mammalian biology, and human disease.

Our interests include:

• Integrins and how they communicate extracellular ligand binding to cytoskeleton assembly and force transduction
• cryoEM of integrin-ligand complexes (with Alan Brown)
• Single molecule studies of conformational change kinetics and force transmission (with TJ Ha)
• Transforming growth factor β and its localized activation at cell surfaces by integrins and proteases
• Stem cells and developmental pathways
• Nervous system development and microglia
• Tyrosine kinases and inside-out signals transmitted by them in transformed cancer cells
• Therapeutics development using deep biological insights into cell surface receptor conformational change