Research Scientist- Animal Models (Biology) - Center for Protein Degradation

Overview

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

Responsibilities

Dana-Farber Cancer Institute (DFCI) and Deerfield Management have entered a multi-year collaboration to create the Center for Protein Degradation (CPD) at DFCI led by Drs. Eric Fischer and Nathanael Gray. The goals of the Center for Protein Degradation are to create a next-generation protein degrader platform and interrogate and advance a large portfolio of protein degrader targets. This is an exceptional opportunity to join a newly founded research center that is pushing the boundaries of targeted protein degradation research and accelerating the translation of basic science into clinical solutions. Join our highly interactive team of scientists and associates to work on testing and creating new avenues of therapeutic intervention.

Job Summary

The Center for Protein Degradation (CPD) seeks a highly motivated individual to join the biology team as a SCIENTIST who will work on various projects focused on the development and validation of molecular glues and degrader molecules for the treatment of cancer. A qualified candidate will lead internal and external research efforts to develop and utilize preclinical mouse models to (1) develop pharmacodynamics (PD) assays to monitor compound activity and efficacy, (2) evaluate compound tolerability to examine potential for adverse events, (3) identify and validate biomarkers correlating with drug response, and (4) design and execute in vivo efficacy studies. The individual will prepare high quality technical reports and summaries that will be used to guide further translational development of candidate molecules. The applicant will provide conceptual insights to research directions, make hands-on contributions to the research, and will regularly present work progress to rest of group.

Responsibilities

• Independently plan, manage, and perform experiments and biology projects. Develop project proposals, timelines and resource needs. Monitor milestones and ensure deliverables are completed on time.
• Develop, implement, and deliver on in vivo translational studies
• Plan and perform in vivo and ex vivo experiments in animal models of cancer; including development and induction of disease models; delivery of candidate drugs; clinical observations; sample harvesting and analyses of histology and molecular endpoints; colony maintenance of genetic disease models
• Develop PD assays to efficiently monitor protein degradation in live animals
• Work closely across groups and functions to explore novel indications and new drug combinations in animal models of cancer
• Collect and analyze experimental data and identify next steps based on outcomes
• Train research technicians and other scientific staff in methods/techniques and supervise on specific projects
• Communicate project deliverables to the leaders across the group, and other senior governance groups when necessary
• Interact and liaise with internal experts, external experts, academic groups, and CROs to establish and direct collaborations and projects
• Prepare papers and publications, if necessary
• Maintain clear and accurate records of experimental work (e.g., experimental methods, results/findings)

Qualifications

Minimum Qualifications

• PhD degree in pharmacology, molecular/cellular biology, biochemistry, or a related discipline with at least 2 years of relevant postdoctoral experience, industrial experience is preferred

• Experience in establishing and working with animal models, with an emphasis on cancer Demonstrated expertise in PD and efficacy experimental design and execution

• Familiarity with various animal-imaging techniques

• Basic knowledge of statistics and experience with common statistical software for biomedical research Proficiency in all common Microsoft Office and GraphPad Prism software

• Excellent communication and presentation skills.
• Scientific drive, demonstrated by a proven track record of publications in peer reviewed journals
• Demonstrated ability to work in a fast-paced and dynamic environment.
• Ability to work independently as well as in a collaborative and team environment
• Excellent organizational and prioritization skills. Strong attention to detail

Preferred Qualifications

• Background in oncology and drug discovery is preferred
• Experience in running multi-faceted projects is preferred
• Experience managing more junior staff is desirable

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.

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