(Contract) Sr. Research Associate, Analytical Development

Employer
Moderna
Location
Cambridge, MA
Salary
Competitive
Posted
March 22 2019
Ref
R1531
Organization Type
Biotech
(Contract) Sr. Research Associate, Analytical Development

The Role:

Moderna is seeking a Research Associate/Senior Research Associate for a contractor position based at Cambridge, MA. The individual in this role will be a highly skilled, talented and motivated scientist that will be focused on method development and characterization of mRNA and raw materials to support mRNA therapeutic development . He/she will participate in performing m RNA method development for raw materials, mRNA drug substance and drug product, method qualifications/validations and transfers. He/she will also perform biophysical characterization of mRNA, kinetic analysis of mRNA, and enzyme kinetic studies. The individual will work with other RAs and Scientists within the Analytical Development and across the Moderna ecosystem. The successful candidate must have a BS with at least 5 years of industry experience, or MS with at least 3 years of industry experience (Analytical, Biochemistry, Molecular Biology, or related science) developing and performing analytical, biochemical, molecular, biophysical and cellular assays. The anticipated time frame for this assignment is 9 months.

Here's What You'll Do:
  • Preparation of samples for characterization studies
  • Performing UV/Tm, DSC and CD analysis on mRNA
  • Performing kinetic analysis of RNA degradation
  • Performing qPCR, Performing SDS PAGE and western blot analysis
  • Undertakes analytical testing using established methods and generate high quality data to support internal drug development activities
  • Participates in method development using HPLC, UHPLC, CE and other analytical instruments
  • Performs degradation studies to support impurity identification and characterization
  • Maintains accurate records of experiments and communicate effectively to the analytical team on analytical findings, issue and solutions
  • Ability to multi-task to meet aggressive timelines, and technology development and research goals
  • Presents the results/findings internally and to cross functional teams
  • Accountable for project success and results delivery


Here's What You'll Bring to the Table:
  • BS with at least 5 years of industry experience, or MS with at least 3 years of industry experience (Analytical, Biochemistry, Molecular Biology, or related science),
  • Experience in developing and performing analytical, molecular, biochemical and/or biophysical assays
  • Experience in performing biophysical characterization of biologics
  • Experience in method development to support drug development
  • Hands on experience with HPLCs and CE
  • Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment
  • Familiarity with nucleic acid therapeutic characterization and lipid nanoparticles is highly desired


Why join Moderna Therapeutics

We are pioneering a new class of medicines made of messenger RNA, or mRNA. The potential implications of using mRNA as a drug are significant and far-reaching. It could transform not only how certain diseases are treated but also how medicines are discovered, developed and manufactured - at a breadth, scale and speed not common in the biopharma industry.

Since our founding in 2011, we have built the industry's leading mRNA technology platform , the infrastructure to accelerate drug discovery and speed early development, a rapidly expanding pipeline , and an unparalleled team . Our development pipeline includes development candidates for mRNA-based vaccines and therapies spanning several therapeutic areas, and we have multiple clinical trials already underway with other development candidates progressing toward the clinic. In addition, we have a number of discovery programs that are advancing toward the development stage.

We invite you to explore our site to learn more about our company and how we are advancing the promise of mRNA science to improve health and impact lives around the world.

Our Mission:
Deliver on the promise of mRNA science to create a new generation of transformative medicines for patients.

#LI-DNI

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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