Postdoctoral Research Fellow

Postdoctoral Fellow Position in Harvard Medical School For

Obesity-Related Neuroscience Research

Two postdoctoral positions are available in the Ozcan Laboratory (www.ozcanlab.com) in the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School.

            The positions are offered to study the role of endoplasmic reticulum (ER) stress signaling in hypothalamic control of metabolic homeostasis, neuron activity and leptin resistance in obesity. The interested candidates can check our recent publications in this area to understand the area of research better:

• Ozcan L, et al. Cell Metabolism. 2009 Jan 7;9(1):35-51. Endoplasmic reticulum stress plays a central role in development of leptin resistance.
• Liu J et al., Cell. 2015 May 21;161(5):999-1011. Treatment of obesity with celastrol.
• Lee J et al., Nature Medicine. 2016 Sep;22(9):1023-32. Withaferin A is a leptin sensitizer with strong antidiabetic properties in mice.
• Feng X, et al., Nature Medicine. 2019 March 4-Online publication. IL1R1 is required for celastrol’s leptin-sensitization and antiobesity effects.

The ideal candidates for both positions should have a Ph.D., M.D. or M.D./Ph.D. degrees with strong experience in neuroscience and molecular biology evident by peer-reviewed publications in reputable journals. Position one requires expertise in patch clamp technique for single cell electrophysiological recording of neurons. Candidates for this position must have expertise in electrophysiological recordings of neurons and stereotaxic surgeries. For position two, candidates should have expertise in neuroscience research and molecular biology: candidates with prior experience in central control of metabolic homeostasis will be given priority for position two.

Interested candidates should forward their research interests, curriculum vitae along with the name and contact information of three referees to Dr. Umut Ozcan; e-mail: umut.ozcan@childrens.harvard.edu