Postdoctoral Associate (Computational Epigenetics of Aging and Cancer) Adams Lab
SBP is a preeminent, independent biomedical research institute dedicated to understanding human biology and disease, and advancing scientific discoveries to profoundly impact human health. For over 40 years, our research has produced breakthroughs in cancer, neuroscience, immunology and children’s diseases, and is anchored by our NCI-designated cancer center and advanced drug discovery capabilities.
Dr. Adams’ lab investigates the impact of chromatin and epigenetics on cellular senescence, aging and cancer. In particular, the lab hypothesizes that age-associated changes in chromatin and epigenetic programming contribute to the dramatic age-associated increase in incidence of cancer. While age is the biggest single risk factor for most cancers, the reason for this is current poorly understood.
A postdoctoral position is available in the lab of Prof Peter D. Adams for ambitious, independent and motivated candidates to join the team investigating the epigenetics of aging and cancer. The successful candidate will use computational and bioinformatics approaches to investigate how age-associated epigenetic events, derived from human and mouse tissues and cell culture models, are related to epigenetic hallmarks of aging and disease, most notably cancer. Datasets will include ChIP-seq, RNA-seq, ATAC-seq, DNA methyl-seq and other large-scale epigenomic and chromatin analyses, including at the single-cell level, as well as results from high throughput chemical and RNAi/CRISPR phenotypic screens.
TO APPLY: Interested candidates should apply online to the SBP career site by submitting one PDF document with a cover letter, CV, references and list of any publications or accomplishments.
Duties and Responsibilities
- Computational analysis and integration of large transcriptomic and epigenetic datasets
- Access of public genetic, epigenetic and transcriptomic large datasets, for integration with those datasets generated in the lab.
- Utilization of existing lab data analysis pipelines
- Building of new data analysis pipelines, e.g. for single cell RNA-seq and ATAC-seq.
- Management of large dataset storage, in databases, lab wiki and lab UCSC browser
- Presentation of results to lab members at weekly lab meetings
- Presentation of results and data within SBP, local La Jolla mtgs and national and international meetings, as appropriate.
- Maintain and initiate collaborations between Adams lab and other labs in SBP, San Diego, US and world wide.
- Ph.D. degree in Computer Science, Bioinformatics, Biostatistics, or Life Sciences or equivalent studies is required
- Previous Postdoc training is not required
- A background in molecular biology and/or biochemistry is a plus
Other Knowledge, Skills and/or Abilities
- General familiarity with wet lab techniques is desired
- Excellent bioinformatic and programming skills (e.g. Perl, Python, C/C++, Java, R or Web applications)
- Strong command of Linux/UNIX operating system
- Strong knowledge and skills in bioinformatics, statistics and next-generation sequencing data analysis
- Ability to use current bioinformatics tools and have an in depth knowledge of advanced sequencing and array-based technologies
- Experience with Illumina NGS data analysis
- Communicates effectively and collaborates well with Principal Investigators and their team members
- Have strong organizational and problem-solving skills
- Possess strong attention to detail, analytical and time management skills
- Excellent communication and interpersonal skills
- Embody the Institute’s core values of Commitment, Collaboration, Communication, Community and Compassion
Sanford Burnham Prebys Medical Discovery Institute is an Equal Opportunity employer – M/F/Veteran/Disability – committed to the hiring, advancement and fair treatment of all individuals. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other protected status as designated by federal, state or local law. For additional information about your rights as an applicant, click HERE.
Sanford Burnham Prebys Medical Discovery Institute will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information.