Postdoctoral scientist, Müschen Laboratory

Location
Los Angeles, California
Salary
Above NIH payscale
Posted
January 03 2019
Position Type
Full Time
Organization Type
Academia

Our group is interested in comparative analyses of normal lymphocyte development and malignant transformation towards leukemia. We cover research areas with relevance to Immunology, Hematology and Cancer Biology. Our research involves experiments with primary human leukemia cells, normal lymphocyte development in humanized mice, leukemia and stem cell transplantation models, mouse genetics, gene editing, optogenetics, classical molecular and cell biology, a strong emphasis on mechanistic studies in oncogenic signal transduction.

Qualifications: PhD in cell or molecular biology, enthusiasm for science, willingness to think beyond established concepts and to try and learn new experimental and analysis tools. The lab takes a team science approach, so being a nice person and a good team player is important as well.

Your application should include in one single PDF:

CV, brief motivation statement, coordinates of three scientific mentors (references)

Methods/Techniques: Flow cytometry, mass spectrometry/quantitative phospho-profiling, CyTOF, mouse genetics, bone marrow transplantation assays, retroviral gene delivery, whole exome sequencing and RNA-seq-analysis of clonal evolution of leukemia, preclinical drug testing in xenotransplantation models.

Recent work of the laboratory: Studying more than 800 patients, our group discovered a new subtype of leukemia (~15%) that can be treated with small molecule antagonists of pre-B cell receptor signaling, a new therapeutic concept that is now being tested in a clinical trial (Cancer Cell 2015). In addition, a recent study from our lab provided a mechanistic explanation for clonal evolution of normal B-cells towards leukemia (Nature Immunology 2016). Our group discovered that B-cell tumors are subject to a unique autoimmunity checkpoint for removal of self-reactive B-cells. Targeted hyperactivation of SYK (Nature 2015), PI3K (Nature Medicine 2016) and ERK (Cancer Cell 2015) in B-cell malignancies represents the functional equivalent of an autoimmunity checkpoint (AIC) to prevent B-cell autoimmunity. AIC-activation is achievable by pharmacological hyperactivation of SYK, PI3K and ERK, thereby leveraging mechanisms of negative selection in the immune system for targeted cancer therapy (Nature Rev Cancer 2018). Most recently, the Müschen laboratory discovered that B-lymphoid transcription factors serve a novel gatekeeper-function by limiting energy-supply to levels that are insufficient to fuel oncogenic transformation (Nature 2017). The full range of metabolic gatekeeper functions of B-cell transcription factors, including their ability to suppress the pentose phosphate pathway (PPP) in B-cell malignancies was revealed in a follow-up study (Cell 2018).

https://www.cityofhope.org/research/systems-biology

http://www.hhmi.org/scientists/markus-muschen

 

 

Apply for Postdoctoral scientist, Müschen Laboratory

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


Upload from your computer

Or import from cloud storage

Your Supplementary Documents must be a .doc, .pdf, .docx, .txt, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from Science Careers by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on Science Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs