Disease resistance genes - snails & schistosomes
Postdoctoral position is available in Michael Blouin’s lab at Oregon State University, Department of Integrative Biology (http://people.oregonstate.edu/~blouinm/).
The aim of this project is to identify genes in the snail, Biomphalaria glabrata, that convey resistance to Schistosoma mansoni, a major parasite of humans that is transmitted by this snail host (https://en.wikipedia.org/wiki/Schistosomiasis). We have mapped major QTL that control infection risk in laboratory populations of snails, and have annotated nearby candidate genes. The goal for this position is to functionally assess candidate genes for their role in resistance. The main approach will be gene knockdowns using RNAi, but may include CRISPR or other techniques. Once causal gene(s) are identified, work will focus on their mechanisms of action, including how they interact with parasite-derived molecules. The long-term goal of this research is to find ways to block transmission of schistosomiasis via interference with the snail host. Biomphalaria and Schistosoma form a well-studied, model host-parasite system with numerous available molecular and genomic resources and established laboratory protocols. We are looking for a creative individual who will also develop their own ideas using this system.
Corvallis, Oregon, is a medium-sized city, set in a beautiful area of the Pacific Northwest. It is well known for its high quality of life that includes a safe, progressive and intellectually vibrant community, and ready access to many outdoor recreational activities.
The successful candidate will hold a PhD in biology or a related science and be able to document substantial expertise in molecular/cellular biology or immunology. Strongly desired qualifications include experience with RNAi and/or alternative gene knockdown/knockout techniques. Other desirable qualifications include experience in microscopy and immunohistochemistry techniques, bioinformatics skills, background in protein biochemistry, and training in immunology. We are looking for a highly motivated and enthusiastic candidate with excellent writing and communication skills. Ability to start in Spring of 2019 would be desirable.
For more information, contact Mike at email@example.com and include “Snail postdoc position” in the title of your email.
Official position description: https://jobs.oregonstate.edu/postings/70041/print_preview
Apply at: https://jobs.oregonstate.edu/postings/69874