Postdoctoral Associate - Human stem cell modeling of developmental disorders

Location
New Haven, Connecticut
Salary
TBD
Posted
December 10 2018
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

A Postdoctoral Associate position is available in the Vaccarino laboratory (http://vaccarinolab.research.yale.edu/) at the Child Study Center, Yale University School of Medicine. The primary aim of the project is to use induced pluripotent stem cells (iPSC) to investigate the pathogenesis of autism spectrum disorders and related conditions. The research focuses on generating new iPSC lines from a well characterized cohort of patients and their first degree family members, deep clinical characterization and neuroimaging data, and perform mechanistic studies of phenotype, transcriptome, epigenome, and physiology. The applicant will be supported by the laboratory experience in organoid generation and bioinformatic analyses, and will collaborate with bioinformaticians who are involved in the analysis of DNA structural and sequence variants in the same patient cohort and in available genomics datasets. The applicant will also have the oppportunity to generate models of autism spectrum disorders by manipulating the genomes of induced pluripotent stem cells using CRISPR technologies to engineer mutations in control iPSCs lines. The candidate will be involved in multidisciplinary research and will interact with experts in several other disciplines, including geneticists, physiologists, and system biologists.

The lab is in the Sterling Hall of Medicine, in the main Yale Medical School campus. 

Qualified candidates should send a CV, a statement of research interests and the names of two references to flora.vaccarino@yale.edu. The candidate must have a Ph.D. and/or M.D., should be an accomplished biomedical scientist with knowledge in molecular and cellular biology and preferably developmental neuroscience.  Excellent command of the English language is required.

Vaccarino lab:

http://medicine.yale.edu/lab/vaccarino/

Program in Neurodevelopment and Regeneration:

http://medicine.yale.edu/neurodevelopment/

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