PhD in Pharmacy and Pharmaceutical Sciences: The role of epidermal lipoxygenase in skin homeostas...

Employer
Cardiff University
Location
Other
Posted
May 09 2017
Position Type
Full Time
Organization Type
Academia

Healthy skin forms a barrier that is essential for preventing infection and loss of water from our bodies. Loss of this barrier occurs during common skin diseases such as psoriasis and eczema, and allows infection during chronic wounds. Lipids (fats) are required to maintain the barrier, but little is known regarding how they do this, with the role of skin lipids in disease a major under-researched area.


Previous studies have discovered several families of lipids that are generated by skin or by blood cells that migrate to the skin during response to injury, or in skin disease. Our preliminary data suggests that several of these may be important in maintaining the health of skin and preventing disease. They are made by a family of proteins (enzymes) called lipoxygenases (LOXs) and include two types of lipids, called phospholipids and ceramides.


The primary objective of this study is to characterise regulation of skin gene expression by LOX-derived lipids. To identify pathways by which skin LOXs regulate physiology, they will be down regulated in cultured human skin by delivery of siRNA using microneedles.



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