Principal Scientist, In Vitro Biology

Employer
Location
Massachusetts
Salary
Competitive
Posted
March 10 2017
Discipline
Life Sciences, Biology
Organization Type
Biotech
Principal Scientist, In Vitro Biology

Position Summary

Moderna is seeking an experienced and motivated cell biologist for a position based in Cambridge, MA.  The ideal candidate will have significant expertise and a broad background in cellular biochemistry and pathway analysis involving nucleic acids to expand our understanding of the impact of modified mRNA on phenotype in cells and tissues.  The individual will introduce, qualify and utilize molecular, biochemical and cellular techniques in immortalized, primary, co-culture and 3D models to investigate the molecular mechanism of chemical and structural modifications on mRNA trafficking, protein translation, protein interactions, innate immune activation and other homeostatic cellular processes in mammalian cells and tissues.  S/he will be responsible for extending our understanding of mRNA biology, and developing biochemical and cellular assays to predict the in vivo activity of modified mRNA. 

Responsibilities

  • Provide scientific guidance and technical expertise for biological assessment of modified mRNA on cross functional platform teams
  • Develop, implement and execute cellular models to inform on the molecular mechanism of chemical and structural modifications on mRNA trafficking, protein translation, protein interactions, innate immune activation and other homeostatic cellular processes in mammalian cells and tissues
  • Independently design and execute studies to understand proteins and cell signaling pathways associated with mRNA delivery
  • Evaluate and incorporate whenever possible cutting-edge technologies and models to drive creative molecular/cellular research
  • Accountable for project strategy, execution, communication of results and follow-up
  • Collaborate broadly with members of the program teams and departments throughout Moderna
  • Establish and foster external collaborations to access additional resources
  • Prepare and present findings at department and project team meetings

Qualifications

  • Ph.D. in Cell Biology, Molecular Biology or In Vitro Pharmacology, with at least 10 years of industry and/or academic experience investigating mechanism of modulation of cellular pathways preferably working with nucleic acids
  • Hands on experience with diverse cell culture models, molecular and cellular techniques, mammalian primary cell culture, and their use in dissecting nucleic acid/protein function
  • Demonstrated understanding of molecular biology, cell biology and biochemistry
  • Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a highly dynamic environment
  • Familiarity with nucleic acid therapeutics and nucleic acid delivery
  • Ability to multi-task to meet aggressive technology development and research goals

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