Postdoctoral Research Position in Translational Retinal Biology at University of California, Davis

Location
California (US)
Salary
$42,800 and up (based on experience)
Posted
March 02 2017
Position Type
Full Time
Organization Type
Academia

Postdoctoral Research Position in Translational Retinal Biology at University of California, Davis

Our laboratory is seeking a full-time postdoctoral research fellow who is motivated, enthusiastic, and enjoys collaborative and independent science. The laboratory focuses on translational eye research involving retinal cell biology, gene editing, nanotechnology, optogenetics, and ophthalmic imaging. Retinal diseases are the first human disorders undergoing clinical trials in gene therapy. As such, you will be involved in highly-translational state-of-the-art technologies that will be important in regenerative medicine research.

Successful candidates will become part of a highly successful and collaborative interdisciplinary team of junior and senior investigators, including retinal biologists, bioengineers, and chemists at UC Davis. As an energetic, successful clinician-scientist junior faculty, I am strongly committed to mentoring the candidate for either academic or industry positions. You will also collaborate closely with the laboratories of renowned scientists including Edward Pugh Jr., PhD and Kit S. Lam, MD, PhD here at UC Davis.

Responsibilities:

Responsibilities of this position will include planning, execution, and presentation of experiments involving:

  • Molecular biology, protein biochemistry, and gene editing techniques (CRISPR/Cas9)
  • Mammalian cell culture techniques, especially retinal pigment epithelial (RPE) cells
  • Rodent research, including ocular injections, dissections, and histology
  • Preparation of biological and chemical reagents; use of viral vectors; ISH, IHC
  • Advanced ocular imaging technologies: OCT, SLO, adaptive optics
  • Learning unique techniques in nanotherapeutics and combinatorial chemistry
  • Collaborate with bioengineers in ocular imaging, optogenetics, and biophotonics
  • Shared lab duties, such as ordering and maintaining lab supplies; maintaining compliance

This is an excellent opportunity for individuals interested in future careers in translational science to gain experience in a stimulating and interactive lab environment. The annual salary is $42,800 and up (based on experience) with a solid benefits package offered by UC Davis School of Medicine. Enjoy living in sunny Northern California - both Davis and Sacramento are conveniently located just 1.5 hours from San Francisco / Bay Area, 1 hour from Napa Valley, and 2 hours from Lake Tahoe; and have very reasonable costs of living.

Requirements:

  • Highly motivated, organized, and responsible individual with excellent communication skills
  • Doctoral degree in biological science (PhD or MD/PhD)
  • Ability to work and troubleshoot independently
  • Previous laboratory experience (1 to 3 years)

The qualified candidate will have earned a doctoral degree in cell biology or neurobiology, or a closely-related field, must provide proof of U.S. citizenship or current eligibility to work in the United States, and be available on or before July 1st, 2017 to apply. This is a full-time appointment, with occasional weekend hours for management of experiments. A 2-year minimum commitment is strongly preferred.

More information about the principal investigator can be found at: http://www.ucdmc.ucdavis.edu/eyecenter/our_team/Yiu%20Bio.pdf. The laboratory is located in Tupper Hall in the UC Davis campus. Candidates should send a letter of interest, including a one-page cover letter* (see notes below) and a curriculum vitae, to Dr. Glenn Yiu at gyiu@ucdavis.edu.  Due to a potential large number of applicants, only those candidates selected for interview will be contacted.

*In the cover letter, please briefly describe your research experience, reason(s) for seeking this position, and future career goals. Please also include some unique skills that do not make it to your CV and some personal hobbies.

Select References:

Yiu G, Tieu EV, Nguyen AT, Wong B, Smit-McBride Z. Genomic Disruption of VEGF-A Expression in Human Retinal Pigment Epithelial Cells using CRISPR-Cas9 Endonuclease. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5490-5497. (PMID: 27768202)

Yiu G, Vuong VS, Oltjen S, Cunefare D, Farsiu S, Garzel L, Roberts J, Thomasy S. Effect of Uveal Melanocytes on Choroidal Morphology in Rhesus Macaques and Humans on Enhanced-Depth Imaging Optical Coherence Tomography. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5764-5771 (PMID: 27792810)

Vuong VS, Moisseiev E, Cunefare D, Farsiu S, Moshiri A, Yiu G. Repeatability of Choroidal Thickness Measurements on Enhanced Depth Imaging OCT using Different Posterior Boundaries. Am J Ophthalmol. 2016 Sep; 169:104-12. (PMID: 27345731)

Yiu G, Chiu SJ, Petrou PA, Stinnett S, Sarin N, Farsiu S, Chew EY, Wong WT, Toth CA. Relationship of Central Choroidal Thickness with Age-Related Macular Degeneration Status. Am J Ophthalmol. 2015 Apr;159(4):617-626. (PMID: 25526948)

Yiu G, Manjunath V, Chiu SJ, Farsiu S, Mahmoud TH. Effect of Anti-Vascular Endothelial Grown Factor Therapy on Choroidal Thickness in Diabetic Macular Edema. Am J Ophthalmol. 2014 Oct; 158:745-751.   (PMID: 24952275)

Yiu G, Pecen P, Sarin N, Chiu SJ, Farsiu S, Mruthyunjaya P, Toth CA. Characterization of the Choroid-Scleral Junction and Suprachoroidal Layer in Healthy Individuals on Enhanced-Depth Imaging Optical Coherence Tomography. JAMA Ophthalmol. 2014 Feb 1;132(2):174-81. (PMID: 24336985)

Yiu G, He Z. Glial Inhibition of CNS Axon Regeneration. Nat Rev Neurosci. 2006 Aug; 7(8):617-27. (PMID: 16858390)

Koprivica V, Cho KS, Park JB, Yiu G, Atwal J, Gore B, Kim JA, Lin E, Tessier-Lavigne M, Chen DF, He Z. EGFR Activation Mediates Inhibition of Axon Regeneration by Myelin and Chondroitin Sulfate Proteoglycans. Science. 2005 Oct 7;310(5745):106-10. (PMID: 16210539)

Park JB*, Yiu G* (*these authors contribute equally), Kaneko S, Wang J, Chang J, He Z. A TNF Receptor Family Member, TROY, is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors. Neuron. 2005 Feb 3;45(3):345-51. Cover Article. (PMID: 15694321)

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