Post Doc Fellow - Lab of Dr. Renato Iozzo

Employer
Thomas Jefferson University and Jefferson Health
Location
Philadelphia, Pennsylvania (US)
Salary
Full Benefits
Posted
March 01 2017
Ref
9211158
Position Type
Full Time
Organization Type
Academia

Post Doc Fellow - Lab of Dr. Renato Iozzo

The position will focus on the biology of two major proteoglycans: decorin and perlecan and their consequent effects on tumor angiogenesis, autophagy, and mitophagy (1-10). The fellow will join an exciting and energetic team of researchers using state-of-the-art techniques in an innovative environment that has led to several groundbreaking discoveries over the last three decades. An additional area of interest of the lab is the study of the biology of the growth factor progranulin (11-12).  This position requires a PhD or M.D. If you are interested, please submit your C.V. and three letters of reference to Renato V. Iozzo at:

  1. Buraschi, S., Neill, T., Goyal, A., Paluzzi, C., Smythies , J., Owens, R. T., Schaefer, L., Torres , A., &Iozzo , R. V. (2013) Decorin causes autophagy in endothelial cells via Peg3. Proc. Natl. Acad. Sci. USA 110, E2582-E2591
  2. Gubbiotti, M.A., Neill, T., Frey, H., Schaefer, L., and Iozzo, R. V. (2015) Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagy. Matrix Biol. 48, 14-25
  3. Gubbiotti, M.A. and Iozzo, R. V. (2015) Proteoglycans regulate autophagy via outside-in signaling :An emerging new concept. Matrix Biol. 48, 6-13
  4. Neill, T., Torres, A. , Buraschi, S., Owens, R. T., Hoek, J., Baffa, R., and Iozzo, R. V. (2014) Decorin induces mitophagy in breast carcinoma cells via PGC-1a and mitostatin. J. Biol. Chem. 289, 4952-4968
  5. Neill, T., Schaefer, L., and Iozzo, R. V. (2014) Instructive roles of extracellular matrix on autophagy. Am. J. Pathol. 184, 2146-2153
  6. Neill, T., Schaefer, L., and Iozzo, R. V. (2016) Decorin as a multivalent therapeutic agent against cancer. Adv. Drug Deliv. Rev. 97, 174-185
  7. Goyal, A., Neill, T., Owens, R. T., Schaefer, L., and Iozzo, R. V. (2014) Decorin activates AMPK , an energy sensor kinase, to induce autophagy in endothelial cells. Matrix Biol. 34, 46-54
  8. Poluzzi, C., Casulli, J., Goyal, A., Mercer, T. J., Neill, T., and Iozzo, R. V. (2014) Endorepellin evokes autophagy in endothelial cells. J. Biol. Chem. 289, 16114-16128
  9. Goyal, A., Gubbiotti, M. A., Chery, D. R., Han, L., and Iozzo, R. V. (2016 ) Endorepellin-evoked autophagy contributes to angiostasis. J. Biol. Chem. 291, 19245-56
  10. Buraschi, S., Xu, S.Q., Stefanello, M., Moskalev, I., Morcavallo, A., Genua, M., Tanimoto, R., Birbe, R., Peiper, S.C., Gomella, L.G., Belfiore A., Black, P.C., Iozzo, R.V., and Morrione, A. (2016) Suppression of progranulin expression inhibits bladder cancer growth and sensitizes cancer cells to cisplatin. Oncotarget. 7, 39980-39995.
  11. Neil, T., Buraschi, S., Goyal, A., Sharpe, C., Natkanski, E., Schaefer, L., Morrione, A., and Iozzo, R.V. (2016) EphA2 is a functional receptor for the growth factor progranulin. J. Cell Biol. 215, 687-703.
  12. Chitramuthu, B., Bateman, A. (2016) Progranulin and the receptor tyrosine kinase EphA2, partners in crime. J.Cell Biol. Spotlight.